Phosphoinositides: Key modulators of energy metabolism.
Phosphoinositides: Key modulators of energy metabolism.
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DOI：
10.1016/j.bbalip.2014.11.008
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Saltiel AR
中科院分区：
文献类型：
--
作者：
Bridges D;Saltiel AR
磷酸肌醇是许多运输和信号传导途径中的关键参与者。关于这些脂质的合成，位置和功能的最新进展大大提高了我们对这些脂质如何以及何时产生以及它们在动物生理学中的作用的理解。特别地，磷酸肌醇在胰岛素信号传导中起核心作用，特别是PtdIns（3，4，5）P3水平的操纵可能是减轻与肥胖和代谢综合征相关的胰岛素抵抗的重要的潜在治疗靶点。本文综述了磷酸肌醇在胰岛素信号转导和能量代谢调节中的代谢、调节和功能作用。这篇文章是题为磷酸肌醇的特刊的一部分。
Phosphoinositides are key players in many trafficking and signaling pathways. Recent advances regarding the synthesis, location and functions of these lipids have dramatically improved our understanding of how and when these lipids are generated and what their roles are in animal physiology. In particular, phosphoinositides play a central role in insulin signaling, and manipulation of PtdIns(3,4,5)P3 levels in particular, may be an important potential therapeutic target for the alleviation of insulin resistance associated with obesity and the metabolic syndrome. In this article we review the metabolism, regulation and functional roles of phosphoinositides in insulin signaling and the regulation of energy metabolism. This article is part of a Special Issue entitled Phosphoinositides.