Spatial arrangement of cerebro‐pontine terminals
Spatial arrangement of cerebro‐pontine terminals
复制标题
脑桥末端的空间排列
DOI：
--
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
M. Möck
中科院分区：
文献类型：
--
作者：
C. Schwarz;M. Möck
了解大脑皮层和小脑的相互作用需要了解大脑小脑信号传递的高度复杂的空间特征。来自一个新皮质部位的脑桥纤维终止于跨越脑桥核（PN）大部分的几个明显分界的斑块，来自不同新皮质区域的纤维终止于同一脑桥区域。为了确定分离的新皮质部位的投射是否在PN中重叠，我们研究了大鼠大部分新皮质的脑桥终末的双顺行追踪。在这些实验中，包括两次注射到两个功能相关的领域，我们能够证明重叠的补丁，虽然总是检测到密切的空间关系。这种非重叠分布与脑桥投射的分隔组织一致，可能是小脑颗粒层中发现的断裂型标测图的基础。通过在初级躯体感觉区的须状代表内使用双重注射，发现新皮质表面上投射到PN中非重叠斑块的两个部位之间的临界距离为600 μm。这与第5层投射神经元的树突树的直径相匹配，表明新皮质投射神经元的非重叠群体具有非重叠的脑桥终末斑块。基于该临界距离和由一个注射部位顺行标记的脑桥体积的估计表明，PN的大小可能非常适合容纳来自所有可能的新皮质部位的一组完整的非重叠脑桥补片。神经学比较杂志435：418-432，2001.© 2001 Wiley利斯公司
Understanding the interaction of the cerebral cortex and cerebellum requires knowledge of the highly complex spatial characteristics of cerebro‐cerebellar signal transfer. Cerebro‐pontine fibers from one neocortical site terminate in several sharply demarcated patches across large parts of the pontine nuclei (PN), and fibers from different neocortical areas terminate in the same pontine region. To determine whether projections from segregated neocortical sites overlap in the PN, we studied double anterograde tracing of cerebro‐pontine terminals from large parts of rat neocortex. In none of these experiments, including double injection into two functionally related areas, were we able to demonstrate overlapping patches, although close spatial relationships were always detected. This non‐overlapping distribution is consistent with a compartmentalized organization of the cerebro‐pontine projection and may be the basis of the fractured type of maps found in the cerebellar granular layer. The critical distance between two sites on the neocortical surface that project to non‐overlapping patches in the PN was found to be 600 μm, by using double injection within the whisker representation of the primary somatosensory area. This matches the diameter of dendritic trees of layer 5 projection neurons, indicating that non‐overlapping populations of neocortical projection neurons possess non‐overlapping patches of pontine terminals. Estimations based on this critical distance and the pontine volume anterogradely labeled by one injection site indicate that the size of the PN may be well suited to accommodate a complete set of non‐overlapping pontine patches from all possible neocortical sites. J. Comp. Neurol. 435:418–432, 2001. © 2001 Wiley‐Liss, Inc.
影响因子：
3.7
作者：
Ghazanfar, AA;Nicolelis, MAL
通讯作者：
Nicolelis, MAL
影响因子：
2.5
作者：
Goldreich, D;Kyriazi, HT;Simons, DJ
通讯作者：
Simons, DJ