Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord
Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord
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DOI：
10.1016/s0002-9440(10)62361-9
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发表时间：
2005-05-01
影响因子：
6
通讯作者：
Lassmann, H
中科院分区：
文献类型：
--
作者：
Bradl, M;Bauer, J;Lassmann, H
T细胞在中枢神经系统(CNS)炎症反应中的中心作用已有很好的文献记载。然而，关于在非炎症中枢神经系统中发现的少数T细胞的信息很少。特别是，CD4(+)和CD8(+)T细胞对渗入完整CNS的淋巴细胞池的贡献，这些细胞在CNS白质和灰质中的位置，以及与退变相一致的T细胞浸润物的细胞组成的变化，基本上是未知的。为了解决这些问题，我们研究了完整和变性大鼠脊髓中的T细胞。在完整的脊髓中，T细胞优先位于灰质内。CD8(+)T细胞多于CD4(+)淋巴细胞。在神经轴突变性或髓鞘变性/少突胶质细胞死亡的病例中，T细胞主要见于变性区域，且数量增加。这些对CD4(+)T细胞亚群的影响比对CD8(+)T细胞亚群的影响更明显。总而言之，这些数据为T细胞在完整和变性的脊髓中的渗透提供了明显的细胞和间隔性偏见的证据。这可能表明，在完整和病变的器官中，CD4(+)和CD8(+)T细胞可能发挥互补作用。
The central role of T cells in inflammatory reactions of the central nervous system (CNS) is well documented. However, there is little information about the few T cells found within the noninflamed CNS. In particular, the contribution of CD4(+) and CD8(+) T cells to the lymphocyte pool infiltrating the intact CNS, the location of these cells in CNS white and gray matter, and changes in the cellular composition of T-cell infiltrates coinciding with degeneration are primarily undefined. To address these points, we studied T cells in the intact and degenerative rat spinal cord. in the intact spinal cord, T cells were preferentially located within the gray matter. CD8(+) T cells were more numerous than CD4(+) lymphocytes. In cases of neuroaxonal degeneration or myelin degeneratioa/oligodendrocyte death, T cells were predominantly seen in areas of degeneration and were present in increased numbers. These effects were more pronounced for the CD4(+) than for the CD8(+) T-cell subset. Collectively, these data provide evidence for a clear cellular and compartmental bias in T-cell infiltration of the intact and degenerative spinal cord. This could indicate that CD4(+) and CD8(+) T cells might fulfill complementary roles in the intact and the diseased organ.