Superoxide production by phagocytic leukocytes.
Superoxide production by phagocytic leukocytes.
复制标题
吞噬白细胞产生超氧化物。
DOI：
10.1084/jem.141.1.257
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发表时间：
1975-01-01
影响因子：
15.3
通讯作者：
Karnovsky, M L
中科院分区：
文献类型：
--
作者：
Drath, D B;Karnovsky, M L
单核吞噬白细胞和多形核白细胞在静止状态下产生和释放超氧化物，这是由吞噬作用刺激的。在所研究的小鼠单核细胞中，肺泡巨噬细胞在吞噬过程中释放的超氧化物最多，其次是正常的腹膜巨噬细胞。酪蛋白诱导和“激活”的巨噬细胞释放的量较少。在豚鼠中，多形核白细胞和酪蛋白诱导的巨噬细胞在吞噬过程中释放超氧化物，而肺泡巨噬细胞则不释放。除了正常的小鼠腹膜巨噬细胞、豚鼠多形核白细胞，可能还有小鼠肺泡巨噬细胞外，超氧化物的释放只占呼吸爆发吞噬作用的一小部分。各种白细胞释放O2-的种类明显不同，这可能反映了该物质的产生和/或破坏(例如，通过歧化酶)。
Mononuclear phagocytic leukocytes, as well as polymorphonuclear leukocytes, produce and release superoxide at rest, and this is stimulated by phagocytosis. Of the mouse monocytic cells studied, alveolar macrophages released the largest amounts of superoxide during phagocytosis, followed by normal peritoneal macrophages. Casein- elicited and "activated" macrophages released smaller quantities. In the guinea pig, polymorphonuclear leukocytes and casein-elicited macrophages were shown to release superoxide during phagocytosis whereas alveolar macrophages did not. Superoxide release accounted for only a small fraction of the respiratory burst of phagocytosis in all but the normal mouse peritoneal macrophage, the guinea pig polymorphonuclear leukocyte, and probably the mouse alveolar macrophage. There are obviously considerable species differences in O2- release by various leukocytes that might reflect both the production and/or destruction (e.g. by dismutase) of that substance.