Composition Gradient High-Throughput Polymer Libraries Enabled by Passive Mixing and Elevated Temperature Operability
Composition Gradient High-Throughput Polymer Libraries Enabled by Passive Mixing and Elevated Temperature Operability
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DOI：
10.1021/acs.chemmater.2c01500
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发表时间：
2022-07
影响因子：
8.6
通讯作者：
Aaron L. Liu;E. M. Dogan-Guner;Michael McBride;R. Venkatesh;M. Gonzalez;E. Reichmanis;M. Grover;J. Meredith
中科院分区：
文献类型：
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作者：
Aaron L. Liu;E. M. Dogan-Guner;Michael McBride;R. Venkatesh;M. Gonzalez;E. Reichmanis;M. Grover;J. Meredith
开发高通量实验（HTE）方法来有效筛选多参数空间是加速发现用于传感器、分离、能源、涂料和其他与社会相关的薄膜应用的高性能多组分材料（例如聚合物共混物、胶体等）的关键。尽管梯度薄膜库样品的生成和表征是实现材料 HTE 的常用方法，但由于需要克服环境条件下其他加工挑战中不利的溶解度和粘度，因此研究许多系统的能力受到阻碍。在该协议中，设计并演示了能够在 110°C 以上工作温度的溶液涂层系统，用于沉积成分梯度聚合物库。该系统配备了定制的耐溶剂被动混合器模块，适用于在环境压力下高温混合聚合物溶液。采用停留时间分布模型来预测使用聚(3-己基噻吩)和聚(苯乙烯)模型系统生成成分梯度膜所需的涂层条件。选择聚（丙烯）和聚（苯乙烯）共混物作为高温梯度薄膜涂层的第一个演示：该共混物代表了一种聚合物系统，由于环境条件下溶解度的限制，传统上很难通过现有的涂层方法生成梯度薄膜。这里开发的方法预计将扩大可通过高通量实验室采样探索的溶液处理材料的范围，并提供有效筛选多参数材料空间和/或填充实现数据驱动材料科学所需的大数据集的途径。
The development of high-throughput experimentation (HTE) methods to efficiently screen multiparameter spaces is key to accelerating the discovery of high-performance multicomponent materials (e.g., polymer blends, colloids, etc.) for sensors, separations, energy, coatings, and other thin-film applications relevant to society. Although the generation and characterization of gradient thin-film library samples is a common approach to enable materials HTE, the ability to study many systems is impeded by the need to overcome unfavorable solubilities and viscosities among other processing challenges under ambient conditions. In this protocol, a solution coating system capable of operating temperatures over 110 °C is designed and demonstrated for the deposition of composition gradient polymer libraries. The system is equipped with a custom, solvent-resistant passive mixer module suitable for high-temperature mixing of polymer solutions at ambient pressure. Residence time distribution modeling was employed to predict the coating conditions necessary to generate composition gradient films using a poly(3-hexylthiophene) and poly(styrene) model system. Poly(propylene) and poly(styrene) blends were selected as a first demonstration of high temperature gradient film coating: the blend represents a polymer system where gradient films are traditionally difficult to generate via existing coating approaches due to solubility constraints under ambient conditions. The methodology developed here is expected to widen the range of solution processed materials that can be explored via high-throughput laboratory sampling and provides an avenue for efficiently screening multiparameter materials spaces and/or populating the large data sets required to enable data-driven materials science.