Ankle-brachial index and the incidence of all-cause mortality and cardiovascular morbidity in a prospective cohort study of a general population
Ankle-brachial index and the incidence of all-cause mortality and cardiovascular morbidity in a prospective cohort study of a general population
复制标题
DOI：
10.1016/j.arteri.2011.01.002
复制
发表时间：
2011-01-01
影响因子：
1.6
通讯作者：
Torres Moreno, Pilar
中科院分区：
文献类型：
--
作者：
Carbayo Herencia, Julio A.;Artigao Rodenas, Luis Miguel;Torres Moreno, Pilar
简介：本研究的目的是调查一般人群样本中踝肱指数 (ABI) 对全因死亡率、复合终点全因死亡率和心血管发病率的预测价值。方法：我们对 1143 名无心血管事件的个体进行了一项前瞻性队列研究，随访时间为 10.8 年（SD = 2.2）。 ABI 分为两个级别：小于 0.9 和 0.9 至 1.4 之间。调整中包括的预测变量包括性别、年龄（截止值：50岁）、高血压、糖尿病、肥胖、高胆固醇血症（截止值：200 mg/dl）、高密度脂蛋白胆固醇（HDLc）/甘油三酯比率、吸烟和高纤维蛋白原血症。使用 Kaplan-Meier 生存曲线和多变量 Cox 比例风险分析。结果：参与者（56.8% 女性）的平均年龄为 47.1 岁（SD = 17.4），范围为 18-91 岁。 6.9% 的样品中 ABI 值 < 0.9。调整后，ABI < 0.9 的全因死亡率风险比 (HR) 为 1.90 [ 95% 置信区间 (CI) 1.10-3.26]，复合全因死亡率和心血管发病率的 HR 为 1.69 (95% CI 1.07-2.67)。结论：在我们的人群中，ABI < 0.9 是独立于随访 10.8 年后的全因死亡率以及复合全因死亡率和心血管发病率。 (C) 2010 爱思唯尔西班牙公司，S.L.和东南亚。版权所有。
Introduction: The aim of this study was to investigate the predictive value of the ankle-brachial index (ABI) in all-cause mortality and composite end-point all-cause mortality and cardiovascular morbidity in a sample of a general population.Methods: We performed a prospective cohort study of 1143 individuals free of cardiovascular events followed up for 10.8 years (SD = 2.2). The ABI was stratified in two levels: less than 0.9 and between 0.9 and 1.4. The predictive variables included in the adjustment were sex, age (cut-off: 50 years), hypertension, diabetes, obesity, hypercholesterolemia (cut-off: 200 mg/dl), high-density lipoprotein-cholesterol (HDLc)/triglyceride ratio, smoking and hyperfibrinogenemia. Kaplan-Meier survival curves and multivariate Cox proportional hazards analysis were used.Results: The mean age of the participants (56.8% female) was 47.1 years (SD = 17.4), range 18-91 years. An ABI value < 0.9 was found in 6.9% of the sample. After adjustment, an ABI of < 0.9 had a hazard ratio (HR) of 1.90 [ 95% confidence interval (CI) 1.10-3.26] for all-cause mortality, and an HR of 1.69 (95% CI 1.07-2.67) for composite all-cause mortality and cardiovascular morbidity.Conclusions: In our population, an ABI < 0.9 was a risk factor independent of all-cause mortality and of composite all-cause mortality and cardiovascular morbidity after a follow-up of 10.8 years. (C) 2010 Elsevier Espana, S.L. and SEA. All rights reserved.