The neuroprotective effects of electroacupuncture on focal cerebral ischemia in monkey
The neuroprotective effects of electroacupuncture on focal cerebral ischemia in monkey
复制标题
电针对猴局灶性脑缺血的神经保护作用。
DOI：
10.3727/036012902816026112
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发表时间：
2002-01-01
影响因子：
0.3
通讯作者：
Cheng, JS
中科院分区：
文献类型：
--
作者：
Gao, HM;Guo, JC;Cheng, JS
本研究旨在探讨电针是否有利于减轻猴大脑中动脉闭塞(MCAO)后的脑缺血损伤。结果表明，大脑中动脉闭塞后，大脑中动脉闭塞。与对照组相比，再灌流后脑电受到严重抑制，恢复较慢。电针，给予穴位之间的百会穴(GV。20)和仁中穴(GV.26)密集-稀疏的波形，在密集或稀疏波终止时可相互转化，有利于脑缺血后脑电的恢复。MCAO时纹状体局部脑血流量(ICBF)下降，而电针显著改善ICBF。脑缺血后神经功能缺失评分明显降低，电针组神经功能缺失评分增加。脑肿胀系数(右/左)在缺血组显著增加，但电针可减弱这种增加。神经病理学研究显示，电针可显著缩小脑梗塞面积(p<；0.05)，增加同侧纹状体和皮质残留细胞的百分比(p<；0.05)。提示电针对猕猴短暂性脑缺血损伤有一定的保护作用。
The present study was designed to investigate whether the electro-acupuncture (EA) is beneficial to extenuate cerebral ischemic injuries following the middle cerebral artery occlusion (MCAO) in monkey. The results indicated that after MCAO. the EEG was severely inhibited, while the EEG recovery was slow after reperfusion compared with the control group. EA, given between the acupuncture points Baihui Point (GV. 20) and Renzhong Point (GV. 26) with a dense-sparse waveforms,which can be transformed into each other when dense or sparse wave is terminated, facilitated the recovery of EEG after ischema. The local cerebral blood flow (ICBF) in the striatum decreased during MCAO, whereas EA improved the ICBF significantly. The neurological deficit scale significantly decreased after ischemia but increased in EA group. The brain swelling coefficient (right/left) increased significantly in the ischemia group, but EA attenuated this increase. The neuropathological study showed that EA could significantly decrease the infarct area (p<0.05) and increase the percentages of the residual cells in the ipsilateral striatum and cortex (p<0.05 respectively). These results implied that EA is effective to extenuate cerebral ischemic injuries following the transient middle artery occlusion in monkeys.