Effects of GABA-mimetic drugs on turnover of histamine in the mouse brain.
Effects of GABA-mimetic drugs on turnover of histamine in the mouse brain.
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GABA 模拟药物对小鼠大脑中组胺周转的影响。
DOI：
10.1254/jjp.41.403
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
K. Saeki
中科院分区：
文献类型：
--
作者：
M. Nishibori;R. Oishi;Y. Itoh;K. Saeki
研究了GABA类似物对小鼠脑内组胺能活动的影响。全身注射蝇草酚(2 mg/kg和5 mg/kg)、THIP(5-15 mg/kg)和氨基氧乙酸(AOAA)(25 mg/kg)，但不注射巴氯芬(2.5-15 mg/kg)，可抑制帕吉林(65 mg/kg)引起的端甲基组胺(t-MH)蓄积。苍蝇酚对帕吉林诱导的t-MH蓄积的抑制作用无地区差异。麝香酚和AOAA还可抑制组氨酸脱羧酶的特异性抑制剂α-氟甲基组氨酸(50 mg/kg)引起的组胺(HA)水平下降。这些结果表明，这些GABA模拟物减少了小鼠大脑中HA的周转。
The effect of GABA-mimetics on histaminergic activity in the mouse brain was investigated. Systemic administration of muscimol (2 and 5 mg/kg), THIP (5-15 mg/kg) and aminooxyacetic acid (AOAA) (25 mg/kg) but not baclofen (2.5-15 mg/kg) inhibited the pargyline (65 mg/kg)-induced accumulation of tele-methylhistamine (t-MH). There was no regional difference in the inhibitory effect of muscimol on the t-MH accumulation by pargyline treatment. Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by alpha-fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase. These results suggest that these GABA-mimetics reduce the HA turnover in the mouse brain.