Effect of apolipoproteins on the induction of hepatic steatosis in rats.
Effect of apolipoproteins on the induction of hepatic steatosis in rats.
复制标题
载脂蛋白对诱导大鼠肝脂肪变性的影响。
DOI：
10.1016/0016-5085(81)90205-5
复制
发表时间：
1981
期刊：
影响因子：
29.4
通讯作者：
J. Hanks
中科院分区：
文献类型：
--
作者：
S. Quarfordt;F. Shelburne;W. Meyers;L. Jakoi;J. Hanks
The incorporation of apolipoprotein E isolated from human very low density lipoproteins on a triglyceride emulsion produced a substantial increment in hepatic triglyceride after 1 h of in vitro perfusion through the isolated liver of a fasted rat. Both gross and microscopic morphology confirmed a substantial steatosis. Perfusions with triglyceride emulsions which contained no apolipoproteins resulted in a modest increment in hepatic triglyceride although considerably less than emulsions with the E protein, and no morphologic features of steatosis. The steatosis induced in the in vitro perfused fasted livers by the emulsions with E protein could be prevented when CIII-1 apoprotein was also incorporated on the emulsion. A fed rat liver perfused with the E-enriched emulsion accumulated significantly less triglyceride than the fasted preparation. These data suggest that the apoprotein patterns of the plasma triglyceride-rich lipoproteins are of considerable importance for the partition of triglyceride between liver and plasma.
