Characterisation of multiple physiological fields within the anatomical core of rat auditory cortex
Characterisation of multiple physiological fields within the anatomical core of rat auditory cortex
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DOI：
10.1016/s0378-5955(03)00182-5
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发表时间：
2003-07-01
期刊：
影响因子：
2.8
通讯作者：
Weinberger, NM
中科院分区：
文献类型：
--
作者：
Rutkowski, RG;Miasnikov, AA;Weinberger, NM
采用单单元和多单元电生理记录研究了大鼠听觉皮层的组织和反应特性。确定了两个局部组织的“核心”场，即主要（A1）和前（AAF）听觉场，以及三个非局部组织的“带”场，即后嗅（PDB），背（DB）和前嗅（ADB）带场。与A1区的神经元相比，AAF区的神经元表现出更广泛的频率调谐，以及更短的最小、模态和平均第一峰潜伏期。此外，AAF单元表现出更高的阈值和最佳SPLs，以及更宽的动态范围。PDB、DB和ADB组的单位对白噪声的反应强烈，对纯音的反应很差或没有反应。核区和带区在响应特性上的差异可能反映了处理听觉刺激不同特征的功能特异性。本研究还结合微电极定位和尼氏染色来确定A1和AAF之间的生理差异是否与细胞结构定义的边界相对应。A1和AAF均位于颞叶皮层1 （Tel）内，其中AAF位于颞叶皮层的前腹侧，表明这两个相邻的、生理上不同的区域在细胞结构上是均匀的。(C) 2003 Elsevier Science B.V.版权所有
The organisation and response properties of the rat auditory cortex were investigated with single and multi-unit electrophysiological recording. Two tonotopically organised 'core' fields, i.e. the primary (A1) and anterior (AAF) auditory fields, as well as three non-tonotopically organised 'belt' fields, i.e. the posterodorsal (PDB), dorsal (DB) and anterodorsal (ADB) belt fields, were identified. Compared to neurones in A1, units in AAF exhibited broader frequency tuning, as well as shorter minimum, modal and mean first spike latencies. In addition, units in AAF showed significantly higher thresholds and best SPLs, as well as broader dynamic ranges. Units in PDB, DB and ADB were characterised by strong responses to white noise and showed either poor or no responses to pure tones. The differences in response properties found between the core and belt fields may reflect a functional specificity in processing different features of auditory stimuli. The present study also combined microelectrode mapping with Nissl staining to determine if the physiological differences between A1 and AAF corresponded to cytoarchitectonically defined borders. Both A1 and AAF were located within temporal cortex 1 (Tel), with AAF occupying an anteroventral subdivision of Tel, indicating that the two neighbouring, physiologically distinct fields are cytoarchitectonically homogeneous. (C) 2003 Elsevier Science B.V. All rights reserved.