Obesity, macrophage migration inhibitory factor, and weight loss
Obesity, macrophage migration inhibitory factor, and weight loss
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DOI：
10.1038/sj.ijo.0802942
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发表时间：
2005-06-01
影响因子：
4.9
通讯作者：
Giroir, BP
中科院分区：
文献类型：
--
作者：
Church, TS;Willis, MS;Giroir, BP
目的：巨噬细胞迁移抑制因子（MIF）升高已被认为是许多疾病的因果机制，包括心血管疾病（CVD）、糖尿病和癌症。身体脂肪过多会增加许多健康状况的风险，包括心血管疾病、糖尿病和癌症。据我们所知，MIF与肥胖状态之间的关系以及体重减轻对血清MIF浓度的影响尚未见报道。在这项研究中，我们检查了参与一项基于行为的减肥计划对肥胖个体中MIF浓度的影响。研究对象：71名男性和女性参加了库珀研究所体重管理项目。参与者主要为女性（68%,n = 48），中年（46.5±9.8岁），重度肥胖（BMI =43.0±8.6）。方法：在参与基于饮食和身体活动的体重管理计划之前和之后，测量血浆MIF浓度和其他标准危险因素。结果：平均随访8.5±3.0个月，平均体重减轻14.4 kg （P< 0.001）。大多数临床危险因素在随访中显著改善。随访时血浆MIF浓度中位数水平（中位数[IQR]； 5.1[3.6 - 10.3]）显著低于基线水平（8.4 [4.3 - 48.8];P = 0.0005）。血浆MIF浓度≥19.5 mg/ nl（基线时最高百分比）的参与者百分比从33.8%下降到5.6% （P< 0.001）。此外，血浆MIF基线浓度升高与β细胞功能障碍标志物相关，MIF降低与β细胞功能改善相关。结论：肥胖但健康个体的循环MIF浓度升高；然而，这种MIF的升高在个体之间并不一致。在循环MIF浓度升高的肥胖个体中，参与体育活动和以饮食为重点的体重管理计划可显著降低MIF。
Objective: Elevated macrophage migration inhibitory factor ( MIF) has been implicated as a causal mechanism in a number of disease conditions including cardiovascular disease ( CVD), diabetes, and cancer. Excess body fat is associated with an increased risk of numerous health conditions including CVD, diabetes, and cancer. To our knowledge, the association between MIF and obesity status and the effect of weight loss on serum MIF concentrations have not been reported. In this study, we examined the effects of participation in a behavior- based weight loss program on MIF concentrations in obese individuals.Subjects: Study participants were 71 men and women enrolled in The Cooper Institute Weight Management Program. Participants were predominantly female ( 68%, n = 48), middle- aged ( 46.5 ± 9.8 y), and severely obese ( BMI =43.0 ± 8.6).Method: Plasma MIF concentrations and other standard risk factors were measured before and after participation in a diet and physical activity based weight management program.Results: The mean follow- up was 8.5± 3.0 months with an average weight loss of 14.4 kg ( P< 0.001). The majority of clinical risk factors significantly improved at follow- up. Median levels of plasma MIF concentration were significantly lower at follow- up ( median [ IQR]; 5.1[ 3.6 - 10.3]) compared to baseline ( 8.4 [ 4.3 - 48.8]; P = 0.0005). The percentage of participants with plasma MIF concentration ≥ 19.5 mg/ nl ( highest tertile at baseline) decreased from 33.8 to 5.6% ( P< 0.001). Further, elevated baseline plasma MIF concentration was associated with markers of β- cell dysfunction and reductions in MIF were associated with improvements in β- cell function.Conclusions: Circulating MIF concentrations are elevated in obese but otherwise healthy individuals; however, this elevation in MIF is not uniform across individuals. In obese individuals with elevated circulating MIF concentrations, participation in physical activity and a dietary- focused weight management program resulted in substantial reduction in MIF.