New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars
New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars
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DOI：
10.1111/j.1524-4725.2006.32195.x
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发表时间：
2006-07-01
影响因子：
2.4
通讯作者：
Shariati, Fazlolah
中科院分区：
文献类型：
--
作者：
Asilian, Ali;Darougheh, Afshin;Shariati, Fazlolah
背景：瘢痕疙瘩和增生性瘢痕是真皮胶原的良性生长，通常会导致严重的生理、心理和美容问题。方法在这项为期12周的单盲临床试验中，69例患者随机分为3组。第1组皮损内注射曲安奈德(TAC，10 mg/m L)，每周一次，共8周。TAC+5-FU组[TAC+5-FU(5-FU)]：0.1mL40 mg/mLTAC加入0.9mL5-FU(50 mg/mL5-FU)。这种组合每周注射一次，持续8周。第3组在每周注射TAC+5-FU的基础上，于第1、4、8周用585 nm闪光灯泵浦的脉冲染料激光(PDL，5~7.5J/cm(2))照射皮损。评估皮损的红斑、瘙痒、柔韧性、高度、长度和宽度。在8周和12周的随访中，所有组在几乎所有指标上都显示出可接受的改善，但在组间比较，TAC+5-FU组和TAC+5-FU+PDL组在统计学上更显著(P
Background Keloids and hypertrophic scars are benign growths of dermal collagen that usually cause major physical, psychological, and cosmetic problems.Methods In this 12-week single-blinded clinical trial, 69 patients were randomly assigned into three study groups. In Group 1, intralesional triamcinolone acetonide (TAC, 10 mg/mL) was injected at weekly intervals for a total of 8 weeks. In Group 2 [TAC+5-fluorouracil (5-FU)], 0.1 mL of 40 mg/mL TAC was added to 0.9 mL of 5-FU (50 mg/mL). This combination was injected weekly for 8 weeks. In Group 3, in addition to weekly TAC+5-FU injection for 8 weeks, lesions were irradiated by 585-nm flashlamp-pumped pulsed-dye laser (PDL, 5-7.5 J/cm(2)) at the 1st, 4th, and 8th weeks. Lesions were assessed for erythema, pruritus, pliability, height, length, and width.Results Sixty patients completed the study. At the 8- and 12-week follow-up visits, all groups showed an acceptable improvement in nearly all measures, but in comparison between groups, these were statistically more significant in the TAC+5-FU and TAC+5-FU+PDL groups (p