Macrophage polarization: The answer to the diet/inflammation conundrum?
Macrophage polarization: The answer to the diet/inflammation conundrum?
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DOI：
10.1016/j.numecd.2011.12.010
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发表时间：
2012-05-01
影响因子：
3.9
通讯作者：
Del Rio, D.
中科院分区：
文献类型：
--
作者：
Dall'Asta, M.;Derlindati, E.;Del Rio, D.
巨噬细胞是一种异质性和普遍存在的细胞群，占不同类型组织细胞含量的15%，是响应病原体、炎症过程、组织稳态和修复的主要细胞介质，并且由于它们能够成为炎性细胞因子的主要来源，其可以通过旁分泌和内分泌机制起作用，因此在动脉粥样硬化和胰岛素抵抗中起关键作用。最近，不同活化的巨噬细胞群体已被描述，这取决于各种各样的微环境信号，现在人们认识到，它们的活化在动脉粥样硬化的发展和进展中起着至关重要的作用。共轭亚油酸和多酚化合物在涉及巨噬细胞的实验模型中调节炎症的能力有很好的证据。这一观察结果为一个有趣的假设留下了空间，即巨噬细胞极化可能代表了特定食物成分可以在人类中发挥抗炎作用的统一机制之一，有助于预防与炎症密切相关的慢性疾病，如动脉粥样硬化。未来的研究应致力于证实这一假设，调查是否生理浓度的食物来源的代谢产物可以扰乱体外巨噬细胞活化。在体内方面，组织中巨噬细胞群体的评估，无论多么复杂，都应包括在观察和干预研究中进行的分析中，以了解巨噬细胞活化是否参与特定饮食方案的抗炎活性。(C)2011爱思唯尔有限公司版权所有。
Macrophages, a heterogeneous and ubiquitous cell population representing up to 15% of the cellular content of different types of tissue, are the principal cell mediators in response to pathogens, inflammation process, tissue homeostasis and repair and play a pivotal role in atherosclerosis and insulin resistance because of their capacity to be the major source of inflammatory cytokines, which can function through paracrine and endocrine mechanisms. Recently, differently activated macrophage populations have been described, depending on a large variety of microenvironmental signals, and it is now recognized that their activation plays a crucial role in the development and progression of atherosclerosis. There is good evidence of the ability of conjugated linoleic acids and polyphenolic compounds to modulate inflammation in experimental models involving macrophages. This observation leaves room to the intriguing hypothesis that macrophage polarization could represent one of the unifying mechanisms through which specific food components can exert anti-inflammatory effects in humans, contributing to the prevention of chronic diseases strongly linked to inflammation, such as atherosclerosis. Future studies should be addressed to substantiate this hypothesis, investigating whether or not physiological concentrations of food-derived metabolites can perturb macrophage activation in vitro. On the in vivo side, the evaluation of macrophage populations in tissues, however complex, should be included among the analyses performed in observational and intervention studies, in order to understand if macrophage activation is involved in the anti-inflammatory activity of a specific dietary regimen. (C) 2011 Elsevier B.V. All rights reserved.