Established cell lines used in cystic fibrosis research.
Established cell lines used in cystic fibrosis research.
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DOI：
10.1016/j.jcf.2004.05.040
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发表时间：
2004-08-01
期刊：
影响因子：
--
通讯作者：
Frizzell, R A
中科院分区：
文献类型：
--
作者：
Gruenert, D C;Willems, M;Frizzell, R A
由于使用原代细胞和组织可用性的限制，永生化细胞系的发展对人类疾病的研究具有显著的益处。来自囊性纤维化（CF）患者的细胞以及来自与CF相关的组织的非CF个体的细胞的永生化对于增强我们对CF的生理、生化和遗传机制的理解以及对于设计用于管理CF病理的治疗策略的开发至关重要。这里介绍和讨论了来自各种组织和物种的永生化细胞的全面列表，重点是上皮细胞。
The development of immortalized cell lines has been a significant benefit to the study of human disease, due to limitations in using primary cells and the availability of tissue. The immortalization of cells from cystic fibrosis (CF) patients as well as cells from non-CF individuals from tissues relevant to CF has been critical to enhancing our understanding of the physiological, biochemical and genetic mechanisms underlying CF and for the development of therapeutic strategies designed to manage CF pathology. A comprehensive list of immortalized cells from various tissue and species, with an emphasis on epithelial cells, is presented and discussed here.