The Laterality of Age-Related Hearing Loss and Depression.
The Laterality of Age-Related Hearing Loss and Depression.
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年龄相关性听力损失和抑郁症的偏侧性。
DOI：
10.1097/mao.0000000000003531
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发表时间：
2022-07-01
影响因子：
2.1
通讯作者：
Golub, Justin S.
中科院分区：
文献类型：
--
作者：
Chern, Alexander;Irace, Alexandria L.;Golub, Justin S.
听力损失（HL）与抑郁症状之间存在已知的关联。目的是确定与左耳还是右耳的关联更强。
一项正在进行的前瞻性流行病学队列研究的横断面分析
西班牙裔社区健康研究（美国，多中心）
5328名年龄≥50岁的成年人
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主要结果是抑郁症状，通过流行病学研究中心抑郁量表 - 10（CESD - 10）进行测量，并进行连续和二分类定义。CESD - 10≥10的受试者被归类为具有临床显著抑郁症状（CSDS）。进行线性和逻辑回归以评估每只耳朵的抑郁症状与听力之间的关联，同时控制助听器使用、年龄、性别、教育水平、研究地点、地理背景、心血管疾病和抗抑郁药使用情况。
平均年龄为58.5±6.3岁。右耳平均纯音听阈（PTA）为20.3±11.7分贝（范围 = 0 - 125），左耳为20.3±12.4分贝（范围 = -2.5 - 120）。对协变量进行调整的多变量回归表明，左耳和右耳的抑郁症状与听力损失之间均存在显著关联。右耳PTA每恶化20分贝，CESD - 10增加0.89分（95%置信区间 = 0.59 - 1.2），CSDS的几率增加1.31倍（1.17 - 1.46）。左耳PTA每恶化20分贝，CESD - 10增加0.85分（0.55 - 1.14），CSDS的几率增加1.34倍（1.20 - 1.49）。
单独右耳和左耳听力恶化均与抑郁症状增加和CSDS几率增加有关。未显示出耳侧优势。
There is a known association between hearing loss (HL) and depressive symptoms. The objective was to establish if there is a stronger association with the left or right ear. Cross-sectional analysis of an ongoing prospective epidemiologic cohort study Hispanic Community Health Study (US, multicentered) 5,328 adults ≥50 years old none The main outcome was depressive symptoms, measured by the 10-Item Center for Epidemiologic Studies Depression Scale-10 (CESD-10) and defined continuously and binarily. Subjects with CESD-10≥10 were categorized as having clinically significant depressive symptoms (CSDS). Linear and logistic regressions were performed to assess the association between depressive symptoms and hearing in each ear, controlling for hearing aid use, age, sex, educational level, study site, geographic background, cardiovascular disease, and antidepressant use. Mean age was 58.5±6.3 years. Mean pure-tone average (PTA) was 20.3±11.7 dB (range=0–125) in the right ear and 20.3±12.4 dB (range=−2.5–120) in the left. Multivariable regression adjusting for covariates demonstrated significant associations between depressive symptoms and HL in both the left and right ear. For every 20-dB worsening in right ear PTA, there was 0.89-point increase in CESD-10 (95% confidence interval=0.59–1.2), and odds of CSDS increased 1.31 times (1.17–1.46). For every 20-dB worsening in left ear PTA, there was a 0.85-point increase in CESD-10 (0.55–1.14), and odds of CSDS increased 1.34 times (1.20–1.49). Worsening hearing in the right and left ears individually was associated with increased depressive symptoms and odds of CSDS. No ear laterality was demonstrated.