Overweight and Obesity Over the Adult Life Course and Incident Mobility Limitation in Older Adults
Overweight and Obesity Over the Adult Life Course and Incident Mobility Limitation in Older Adults
复制标题
DOI：
10.1093/aje/kwp007
复制
发表时间：
2009-04-15
影响因子：
5
通讯作者：
Kritchevsky, Stephen B.
中科院分区：
文献类型：
--
作者：
Houston, Denise K.;Ding, Jingzhong;Kritchevsky, Stephen B.
中老年人肥胖预示着活动受限;然而，超重和/或肥胖在成年生活过程中的累积效应尚不清楚。在健康、衰老和身体组成研究（n = 2，845）中，在基线（1997-1998）年龄为70-79岁的社区居住的美国成年人中检查了青年、中年和成年后期超重和/或肥胖之间的关联及其对活动受限事件的累积效应。体重指数是通过使用25岁和50岁时的回忆体重和70-79岁时的测量体重计算的。在7年的随访中，每半年评估一次活动受限（行走1/4英里（0.4 km）或爬10级台阶困难），43.0%的男性和53.7%的女性报告了这一情况。与体重正常的人相比，在所有3个时间点超重或肥胖的男性和女性的活动受限风险增加（风险比= 1.61，95%置信区间：1.25，2.06和风险比= 2.85，95%置信区间：2.15，3.78）。此外，对于男性肥胖和女性超重和/或肥胖的累积效应，活动受限的风险存在显著的分级反应（P < 0.0001）。早年出现超重和肥胖会增加老年人活动受限的风险。
Obesity in middle and old age predicts mobility limitation; however, the cumulative effect of overweight and/or obesity over the adult life course is unknown. The association between overweight and/or obesity in young, middle, and late adulthood and its cumulative effect on incident mobility limitation was examined among community-dwelling US adults aged 70-79 years at baseline (1997-1998) in the Health, Aging and Body Composition Study (n = 2,845). Body mass index was calculated by using recalled weight at ages 25 and 50 years and measured weight at ages 70-79 years. Mobility limitation (difficulty walking 1/4 mile (0.4 km) or climbing 10 steps) was assessed semiannually over 7 years of follow-up and was reported by 43.0% of men and 53.7% of women. Men and women who were overweight or obese at all 3 time points had an increased risk of mobility limitation (hazard ratio = 1.61, 95% confidence interval: 1.25, 2.06 and hazard ratio = 2.85, 95% confidence interval: 2.15, 3.78, respectively) compared with those who were normal weight throughout. Furthermore, there was a significant graded response (P < 0.0001) on risk of mobility limitation for the cumulative effect of obesity in men and overweight and/or obesity in women. Onset of overweight and obesity in earlier life contributes to an increased risk of mobility limitation in old age.