Ultrasmall zirconium carbide nanodots for synergistic photothermal-radiotherapy of glioma
Ultrasmall zirconium carbide nanodots for synergistic photothermal-radiotherapy of glioma
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DOI：
10.1039/d2nr04239h
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发表时间：
2022-09-13
期刊：
影响因子：
6.7
通讯作者：
Wang, Xianwen
中科院分区：
文献类型：
--
作者：
Yin, Mengyuan;Chen, Xiangcun;Wang, Xianwen
胶质瘤具有高度侵袭性、进行性和致死性的特点。此外，传统治疗方法在治疗胶质瘤方面效果不佳。为了克服这一挑战，放疗（RT）与光热治疗（PTT）相结合的协同疗法被提出并被广泛探索，作为一种高度可行的癌症治疗策略。本文成功合成了具有高近红外吸收和强光子衰减的超小碳化锆纳米点，用于胶质瘤的协同PTT-RT。采用液体剥脱法制备了平均尺寸约为4.36 nm的ZrC-PVP纳米点，并采用表面活性剂聚乙烯吡咯烷酮（PVP）对其进行了改性，在近红外区具有良好的吸收和光热转换效率（53.4%）。此外，由于ZrC-PVP纳米点具有优异的光子衰减能力，还可以作为放射增敏剂杀死轻度PTT后残留的肿瘤细胞，从而通过RT和PTT联合治疗达到显著的协同治疗效果。最重要的是，体外和体内实验结果进一步验证了ZrC-PVP NDs在注射剂量下的高生物安全性。本研究系统评价了ZrC-PVP纳米材料用于胶质瘤治疗的可行性，为锆基纳米材料在光热放疗中的应用提供了依据。
Glioma is characterized by highly invasive, progressive, and lethal features. In addition, conventional treatments have been poorly effective in treating glioma. To overcome this challenge, synergistic therapies combining radiotherapy (RT) with photothermal therapy (PTT) have been proposed and extensively explored as a highly feasible cancer treatment strategy. Herein, ultrasmall zirconium carbide (ZrC) nanodots were successfully synthesized with high near-infrared absorption and strong photon attenuation for synergistic PTT-RT of glioma. ZrC-PVP nanodots with an average size of approximately 4.36 nm were prepared by the liquid exfoliation method and modified with the surfactant polyvinylpyrrolidone (PVP), with a satisfactory absorption and photothermal conversion efficiency (53.4%) in the near-infrared region. Furthermore, ZrC-PVP nanodots can also act as radiosensitizers to kill residual tumor cells after mild PTT due to their excellent photon attenuating ability, thus achieving a significant synergistic therapeutic effect by combining RT and PTT. Most importantly, both in vitro and in vivo experimental results further validate the high biosafety of ZrC-PVP NDs at the injected dose. This work systematically evaluates the feasibility of ZrC-PVP NDs for glioma treatment and provides evidence of the application of zirconium-based nanomaterials in photothermal radiotherapy.