Nanotechnology inspired tools for mitochondrial dysfunction related diseases.
Nanotechnology inspired tools for mitochondrial dysfunction related diseases.
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DOI：
10.1016/j.addr.2015.12.024
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发表时间：
2016-04-01
影响因子：
16.1
通讯作者：
Dhar S
中科院分区：
文献类型：
--
作者：
Wen R;Banik B;Pathak RK;Kumar A;Kolishetti N;Dhar S
线粒体功能障碍被认为是各种疾病的主要因素，包括癌症、心血管疾病、糖尿病、神经障碍和一组所谓的“线粒体功能障碍相关疾病”。在靶位于线粒体中的疾病中获得治疗效率的主要障碍之一是靶在这种区室化的细胞器中的可接近性，其对离子和分子的内化施加障碍。随着时间的推移，开发了不同的工具和技术来提高线粒体作用药物的治疗指数。纳米技术已展开为一个逻辑和令人鼓舞的工具，用于以受控和有针对性的方式提供治疗，同时减少药物过量的副作用。量身定制的基于纳米医学的疗法可以成为与线粒体功能障碍相关的疾病的工具箱中的一个很好的工具。在这篇综述中，我们提出了一个广泛的覆盖范围内的可能的治疗目标在线粒体的不同舱室的癌症，心血管和线粒体功能障碍相关的疾病。
Mitochondrial dysfunctions are recognized as major factors for various diseases including cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases so called “mitochondrial dysfunction related diseases”. One of the major hurdles to gain therapeutic efficiency in diseases where the targets are located in the mitochondria is the accessibility of the targets in this compartmentalized organelle that imposes barriers towards internalization of ions and molecules. Over the time, different tools and techniques were developed to improve therapeutic index for mitochondria acting drugs. Nanotechnology has unfolded as one of the logical and encouraging tools for delivery of therapeutics in controlled and targeted manner simultaneously reducing side effects from drug overdose. Tailor-made nanomedicine based therapeutics can be an excellent tool in the toolbox for diseases associated with mitochondrial dysfunctions. In this review, we present an extensive coverage of possible therapeutic targets in different compartments of mitochondria for cancer, cardiovascular, and mitochondrial dysfunction related diseases.