High SARS-CoV-2 antibody prevalence among healthcare workers exposed to COVID-19 patients
High SARS-CoV-2 antibody prevalence among healthcare workers exposed to COVID-19 patients
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DOI：
10.1016/j.jinf.2020.05.067
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发表时间：
2020-09-01
影响因子：
28.2
通讯作者：
Wu, Chao
中科院分区：
文献类型：
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作者：
Chen, Yuxin;Tong, Xin;Wu, Chao
检测了105名与4名实验室确诊的2019年冠状病毒病（COVID-19）患者接触的医护人员（HCWs）的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）血清阳性率。这些医护人员在被确定为密切接触者后，立即被隔离14天。鼻咽拭子样本于隔离第1天和第14天采集，血清样本于隔离第14天采集。酶免疫法和微量中和试验检测105例HCW血清学阳性率为17.14%（18/105），而拭子标本SARS-CoV-2 RNA检测均为阴性。风险分析显示戴口罩可降低感染风险（比值比[OR]，0.127，95%置信区间[CI] 0.017，0.968），而当接触COVID-19患者时，医生可能有更高的血清转化风险（OR，346.837，95% CI 8.924，13479.434），与接触同事的医护人员、接触病人的护士和一般服务助理比较。我们的研究表明，血清学检测有助于在与COVID-19患者的密切接触者中识别SARS-CoV-2的无症状或亚临床感染。(C)2020年英国传染病协会。由爱思唯尔有限公司出版。保留所有权利。
The seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was examined among 105 healthcare workers (HCWs) exposed to four patients who were laboratory confirmed with coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2 infection. These HCWs were immediately under quarantine for 14 days as soon as they were identified as close contacts. The nasopharyngeal swab samples were collected on the first and 14th day of the quarantine, while the serum samples were obtained on the 14th day of the quarantine. With the assay of enzyme immunoassay (EIA) and microneutralization assay, 17.14% (18/105) of HCWs were seropositive, while their swab samples were found to be SARS-CoV-2 RNA negative. Risk analysis revealed that wearing face mask could reduce the infection risk (odds ratio [OR], 0.127, 95% confidence interval [CI] 0.017, 0.968), while when exposed to COVID-19 patients, doctors might have higher risk of seroconversion (OR, 346.837, 95% CI 8.924, 13479.434), compared with HCWs exposed to colleagues as well as nurses and general service assistants who exposed to patients. Our study revealed that the serological testing is useful for the identification of asymptomatic or subclinical infection of SARS-CoV-2 among close contacts with COVID-19 patients. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.