Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia
Frequency of FLT3 mutations in childhood acute lymphoblastic leukemia
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DOI：
10.1007/s12032-008-9146-z
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发表时间：
2009-12-01
期刊：
影响因子：
3.4
通讯作者：
Tzortzatou-Stathopoulou, F.
中科院分区：
文献类型：
--
作者：
Braoudaki, M.;Karpusas, M.;Tzortzatou-Stathopoulou, F.
FLT 3突变偶尔在急性淋巴细胞白血病（ALL）中观察到。这些最常见的表现为内部串联重复（ITD）和激活环（AL）突变。本研究调查了86例诊断为ALL的儿童患者中FLT 3突变的发生率以及常见RAS突变的共存情况。观察到FLT 3/AL突变率占ALL病例总数的2.3%（2/86），超二倍体病例的发生率为22%（2/9）。这与先前的研究一致，表明与超二倍体相关的患者亚组的发生率较高。
FLT3 mutations are occasionally observed in acute lymphoblastic leukemia (ALL). These most frequently manifest as internal tandem duplications (ITD) and activation loop (AL) mutations. This study investigated the incidence of FLT3 mutations in 86 pediatric patients diagnosed with ALL and the co-presence of common RAS mutations. A 2.3% (2/86) FLT3/AL mutation rate in terms of total ALL cases and a 22% (2/9) incidence in hyperdiploid cases was observed. This is in accordance to previous studies indicating a higher incidence in the patient subgroup associated with hyperdiploidy.