Growth factors and mitogen activated protein kinases
Growth factors and mitogen activated protein kinases
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DOI：
10.1161/01.hyp.31.1.152
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发表时间：
1998-01-01
期刊：
影响因子：
8.3
通讯作者：
Bonventre, JV
中科院分区：
文献类型：
--
作者：
Force, T;Bonventre, JV
哺乳动物细胞通过激活多种信号转导途径来响应外部刺激，其最终导致常规反应，如增殖、生长停滞、肥大、分化或凋亡。在脊椎动物中，导致增殖性或肥大性生长的许多刺激的作用汇聚在一组细胞激酶级联上，这些级联统称为促分裂原活化蛋白（MAP）激酶级联。这些MAP激酶与血管平滑肌细胞增殖和肥大有关，这些反应是高血压病理生理学的核心。在这篇综述中，我们将研究如何增殖和肥大刺激激活这些MAP激酶级联，什么是激活基因表达的后果，以及这些信号如何驱动细胞进入上述的刻板反应之一。
Mammalian cells respond to external stimuli by activation of a variety of signal transduction pathways, which culminate in stereotypical responses, such as proliferation, growth arrest, hypertrophy, differentiation, or apoptosis. In vertebrates the actions of many stimuli resulting in proliferative or hypertrophic growth converge on a set of cellular kinase cascades, which are collectively called the mitogen-activated protein (MAP) kinase cascades. These MAP kinases have been implicated in vascular smooth muscle cell proliferation and hypertrophy, responses that are central to the pathophysiology of hypertension. In this review, we will examine how proliferative and hypertrophic stimuli activate these MAP kinase cascades, what are the consequences of that activation on gene expression, and how do these signals drive the cell into one of the stereotypical responses noted above.