The abundance of fecal Faecalibacterium prausnitzii in relation to obesity and gender in Chinese adults
The abundance of fecal Faecalibacterium prausnitzii in relation to obesity and gender in Chinese adults
复制标题
中国成年人粪便中普氏粪杆菌丰度与肥胖和性别的关系
DOI：
10.1007/s00203-013-0942-2
复制
发表时间：
2014-01-01
影响因子：
2.8
通讯作者：
Shen, Jian
中科院分区：
文献类型：
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作者：
Feng, Jie;Tang, Huang;Shen, Jian
性别和肥胖对人类结肠prausnitzii Feacalibacterium丰度的影响目前尚不清楚。我们收集了54名肥胖和54名性别和年龄匹配的正常体重的中国成年人的粪便样本，并使用定量PCR方法量化了粪便中prausnitzii的16S rRNA基因拷贝数占肠道细菌总数的百分比。肥胖和瘦弱受试者粪便中prausnitzi的数量无显著差异。男性粪便F. prausnitzii含量明显低于女性，且男性粪便F. prausnitzii含量与空腹血糖水平呈显著正相关，女性粪便F. prausnitzii含量与空腹血糖水平呈显著正相关。我们的研究结果表明，在研究肠道F. prausnitzii与疾病的关系时，除了研究对象的地理位置、种族、饮食和肠道运输时间等其他因素外，还必须考虑性别效应。
The influence of gender and obesity on the abundance of human colonic Feacalibacterium prausnitzii is currently unclear. We collected fecal samples from 54 obese and 54 sex- and age-matched normal-weight Chinese adults and quantified the fecal F. prausnitzii as percentage of 16S rRNA gene copies of F. prausnitzii accounting to that of total gut bacteria with quantitative PCR. The fecal F. prausnitzii amount was not significantly different between obese and lean subjects. Men possessed significantly lower level of fecal F. prausnitzii than women, and the significant and positive correlation of fecal F. prausnitzii quantity with fasting glucose level was observed in men, not in women. Our results suggest that the gender effect, in addition to other factors including the geographic location, ethnicity, diet and gut transit times of study subjects, has to be considered when studying the relationship between gut F. prausnitzii and diseases.