Cone-beam volume CT breast imaging: Feasibility study
Cone-beam volume CT breast imaging: Feasibility study
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DOI：
10.1118/1.1461843
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发表时间：
2002-05-01
期刊：
影响因子：
3.8
通讯作者：
Ning, R
中科院分区：
文献类型：
--
作者：
Chen, B;Ning, R
使用胶片/屏幕组合或数字技术的x射线投影乳房x线照相术已被证明是目前可用于早期发现乳腺癌的最有效的成像方式。然而，固有的结构叠加使得小癌（几毫米大小）在隐匿性或致密性乳房中难以发现，导致高假阳性活检率。使用平板探测器（fpd）的锥束x射线投影容积成像可以获得三维乳房图像，从而更准确地诊断病变的结构和模式，同时消除乳房的硬压迫。本文在上述技术的基础上提出了一种新的锥形束体积ct乳腺成像技术（CBVCTBI）。通过各种计算机模拟，解决了系统和成像技术的关键问题，包括x射线成像几何结构和相应的重建算法、乳腺组织和病变的x射线特征、x射线设置技术、吸收剂量估计。以及x射线散射对图像质量的定量影响。初步的仿真结果支持了所提出的CVBCTBI乳房成像模式的可行性和实用性。吸收剂量水平与目前的乳房x线摄影相当，不会成为该成像技术的突出问题。与传统乳房x线摄影相比，本研究提出的具有各向同性空间分辨率的成像技术将有可能提供更好的乳腺肿瘤低对比度检测和更准确的乳腺病变定位。(C) 2002年美国医学物理学家协会。
X-ray projection mammography, using a film/screen combination, or digital techniques, has proven to be the most effective imaging modality currently available for early detection of breast cancer. However, the inherent superimposition of structures makes a small carcinoma (a few millimeters in size) difficult to detect when it is occult or in dense breasts, leading to a high false-positive biopsy rate. Cone-beam x-ray-projection-based volume imaging using flat panel detectors (FPDs) may allow obtaining three-dimensional breast images, resulting in more accurate diagnosis of structures and patterns of lesions while eliminating the hard compression of breasts. This article presents a novel cone-beam volume computed tomographic breast imaging (CBVCTBI) technique based on the above techniques. Through a variety of computer simulations, the key issues of the system and imaging techniques were addressed, including the x-ray imaging geometry and corresponding reconstruction algorithms, x-ray characteristics of breast tissue and lesions, x-ray setting techniques, the absorbed dose estimation. and the quantitative effect of x-ray scattering on image quality. The preliminary simulation results support the proposed CVBCTBI modality for breast imaging in respect to its feasibility and practicability. The absorbed dose level is comparable to that of current mammography and will not be a prominent problem for this imaging technique. Compared to conventional mammography, the proposed imaging technique with isotropic spatial resolution will potentially provide significantly better low-contrast detectability of breast tumors and more accurate location of breast lesions. (C) 2002 American Association of Physicists in Medicine.