Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates:: Correlation with outcome in solid organ transplant recipients with Cryptococcosis

Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates:: Correlation with outcome in solid organ transplant recipients with Cryptococcosis
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DOI:
10.1128/aac.00990-07
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发表时间:
2008-02-01
影响因子:
4.9
通讯作者:
Singh, Nina
Singh, Nina
中科院分区:
医学2区
文献类型:
--
作者:
Kontoyiannis, Dimitrios P.;Lewis, Russell E.;Singh, Nina

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我们观察到CIs和抗真菌药物对来自实体器官移植患者的59株新型隐球菌分离株中的53株(90%)具有协同相互作用,这可能是接受这些免疫抑制剂的隐球菌患者获得更好结果的原因。
Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.