Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study
Pregnancy serum concentrations of perfluorinated alkyl substances and offspring behaviour and motor development at age 5-9 years - a prospective study
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DOI：
10.1186/1476-069x-14-2
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发表时间：
2015-01-07
影响因子：
6
通讯作者：
Toft, Gunnar
中科院分区：
文献类型：
--
作者：
Hoyer, Birgit Bjerre;Ramlau-Hansen, Cecilia Host;Toft, Gunnar
背景：在动物研究中，全氟烷基物质影响生长和神经行为结果。人类流行病学研究很少。目的是调查妊娠血清中全氟辛酸盐（PFOA）和全氟辛烷磺酸盐（PFOS）浓度与5-9岁的后代行为和运动发育之间的关系。来自INUENDO队列的母体血清对来自格陵兰、哈尔科夫（乌克兰）和华沙（波兰）的1，106对母子进行了全氟辛烷磺酸和全氟辛酸分析，使用液相色谱串联质谱法。将暴露分组为国家特定和汇总三分位数，并用作统计分析的连续变量。在随访期间（2010-2012年），分别通过2007年发展协调障碍问卷（DCDQ）和力量和困难问卷（SDQ）测量儿童运动发育和行为。暴露结果的关联进行了分析，通过多元Logistic和线性回归analysis.Results：在汇总分析，比值比（OR）（95%置信区间（CI））为多动症为3.1（1.3，7.2）比较产前暴露于最高的PFOA三分位数与那些暴露于最低的PFOA三分位数的儿童。将全氟辛烷磺酸含量最高的三分位数儿童与全氟辛烷磺酸含量最低的三分位数儿童进行比较，结果显示，多动的OR值升高，但在统计学上不显著（OR（95% CI）1.7（0.9，3.2））。在格陵兰，全氟辛烷磺酸升高与SDQ总分较高有关，表明行为问题较多（贝塔（95%可信区间）= 1.0（0.1，2.0）），全氟辛酸升高与多动症子量表得分较高有关，表明多动症行为较多（贝塔（95%可信区间）= 0.5（0.1，0.9））。出生前全氟辛烷磺酸和全氟辛酸暴露与电机difficulties.Conclusions：出生前暴露于全氟辛烷磺酸和全氟辛酸可能有一个小到中度的影响儿童的神经行为发育，特别是在多动症的行为。格陵兰岛的相关性最强，那里的暴露对比度最大。
Background: In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5-9 years of age.Methods: Maternal sera from the INUENDO cohort (2002-2004) comprising 1,106 mother-child pairs from Greenland, Kharkiv (Ukraine) and Warsaw (Poland) were analysed for PFOS and PFOA, using liquid-chromatography-tandem-mass-spectrometry. Exposures were grouped into country specific as well as pooled tertiles as well as being used as continuous variables for statistical analyses. Child motor development and behaviour at follow-up (2010-2012) were measured by the Developmental Coordination Disorder Questionnaire 2007 (DCDQ) and Strength and Difficulties Questionnaire (SDQ), respectively. Exposure-outcome associations were analysed by multiple logistic and linear regression analyses.Results: In the pooled analysis, odds ratio (OR) (95% confidence interval (CI)) for hyperactivity was 3.1 (1.3, 7.2) comparing children prenatally exposed to the highest PFOA tertile with those exposed to the lowest PFOA tertile. Comparing children in the highest PFOS tertile with those in the lowest PFOS tertile showed elevated but statistically non-significant OR of hyperactivity (OR (95% CI) 1.7 (0.9, 3.2)). In Greenland, elevated PFOS was associated with higher SDQ-total scores indicating more behavioural problems (beta (95% CI) = 1.0 (0.1, 2.0)) and elevated PFOA was associated with higher hyperactivity sub-scale scores indicating more hyperactive behaviour (beta (95% CI) = 0.5 (0.1, 0.9)). Prenatal PFOS and PFOA exposures were not associated with motor difficulties.Conclusions: Prenatal exposure to PFOS and PFOA may have a small to moderate effect on children's neuro-behavioural development, specifically in terms of hyperactive behaviour. The associations were strongest in Greenland where exposure contrast is largest.