Association between vitamin C intake and the risk of pancreatic cancer: a meta-analysis of observational studies
Association between vitamin C intake and the risk of pancreatic cancer: a meta-analysis of observational studies
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DOI：
10.1038/srep13973
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发表时间：
2015-09-11
影响因子：
4.6
通讯作者：
He, Qiang
中科院分区：
文献类型：
--
作者：
Fan, Hua;Kou, Jiantao;He, Qiang
对维生素C摄入量与胰腺癌风险之间关系的量化仍然存在矛盾。因此，我们进行了荟萃分析，以评估它们之间的关联。通过检索PubMed和Web of Knowledge（截至2014年9月）确定相关研究。采用随机效应模型对数据进行联合收割机组合分析。进行敏感性分析和发表偏倚分析。本荟萃分析使用了17项研究的数据，包括4827例胰腺癌病例。汇总结果表明，最高维生素C摄入量与最低维生素C摄入量相比，与胰腺癌风险降低显著相关[汇总相对风险（RR）= 0.705，95%CI = 0.612-0.811，I-2 = 42.3%]。在白人[汇总RR = 0.741，95%CI = 0.626-0.876]、亚裔[汇总RR = 0.455，95%CI = 0.275-0.754]和混合人群[汇总RR = 0.677，95%CI = 0.508-0.901]中，相关性也显著。没有发现发表偏倚。我们的分析表明，较高的维生素C摄入量可能会降低胰腺癌的风险。
Quantification of the association between the intake of vitamin C and risk of pancreatic cancer is still conflicting. We therefore conducted a meta-analysis to assess the association between them. Pertinent studies were identified by a search of PubMed and Web of Knowledge through September of 2014. A random effects model was used to combine the data for analysis. Sensitivity analysis and publication bias were conducted. Data from 17 studies including 4827 pancreatic cancer cases were used in this meta-analysis. Pooled results suggested that highest vitamin C intake amount versus lowest amount was significantly associated with reduced the risk of pancreatic cancer [summary relative risk (RR) = 0.705, 95%CI = 0.612-0.811, I-2 = 42.3%]. The associations were also significant both in Caucasian [summary RR = 0.741, 95%CI = 0.626-0.876], Asian [summary RR = 0.455, 95%CI = 0.275-0.754] and Mixed population [summary RR = 0.677, 95%CI = 0.508-0.901]. No publication bias was found. Our analysis suggested that the higher intake of vitamin C might reduce the risk of pancreatic cancer.