Lateralisation of striatal function:: evidence from 18F-dopa PET in Parkinsion's disease
Lateralisation of striatal function:: evidence from 18F-dopa PET in Parkinsion's disease
复制标题
DOI：
10.1136/jnnp.2004.055079
复制
发表时间：
2005-09-01
影响因子：
11
通讯作者：
Brooks, DJ
中科院分区：
文献类型：
--
作者：
Cheesman, AL;Barker, RA;Brooks, DJ
目的：帕金森氏病（PD）中认知变化的病因是多因素的，但多巴胺能通路的中断可能是一个重要的贡献。本研究旨在利用F-18-6-fluorodopa正电子发射断层扫描技术研究多巴胺能系统在两种执行任务中的作用（F-18-多巴PET）在具有早期认知改变的PD受试者中的应用。对16名非痴呆、非抑郁的PD受试者进行伦敦塔（TOL）空间规划任务、言语工作记忆任务（VWMT）和F-18-多巴PET评估，都是早期帕金森病的发病者统计参数映射（SPM）定位的大脑区域，其中F-18-多巴的摄取与性能评分协变。额叶皮质静息葡萄糖代谢进行了评估与F-18-氟-2-脱氧-D-葡萄糖（F-18-FDG）PET.Results：SPM局部显着的协变右尾状核F-18-多巴摄取（Ki）和TOL评分之间，左前壳核Ki和VWMT性能。没有显着的协变之间的任务分数和F-18-多巴Ki值在边缘或皮质区域。额叶皮质葡萄糖代谢被保存在所有cases.Conclusions：这些研究结果支持纹状体多巴胺能耗竭的执行功能的早期损害中看到PD的一个致病作用。他们认为，空间和口头执行任务需要完整的右，左纹状体，分别，并暗示，认知变化的模式表现出的PD患者可能反映了差异多巴胺损失的两个纹状体复合体。
Objectives: The aetiology of the cognitive changes seen in Parkinson's disease (PD) is multifactorial but it is likely that a significant contribution arises from the disruption of dopaminergic pathways. This study aimed to investigate the contribution of the dopaminergic system to performance on two executive tasks using F-18-6-fluorodopa positron emission tomography (F-18-dopa PET) in PD subjects with early cognitive changes.Methods: 16 non-demented, non-depressed PD subjects were evaluated with the Tower of London (TOL) spatial planning task, a verbal working memory task (VWMT) and F-18-dopa PET, all known to be affected in early PD. Statistical parametric mapping (SPM) localised brain regions in which F-18-dopa uptake covaried with performance scores. Frontal cortical resting glucose metabolism was assessed with F-18-fluoro-2-deoxy-D-glucose (F-18-FDG) PET.Results: SPM localised significant covariation between right caudate F-18-dopa uptake (Ki) and TOL scores and between left anterior putamen Ki and VWMT performance. No significant covariation was found between task scores and F-18-dopa Ki values in either limbic or cortical regions. Frontal cortical glucose metabolism was preserved in all cases.Conclusions: These findings support a causative role of striatal dopaminergic depletion in the early impairment of executive functions seen in PD. They suggest that spatial and verbal executive tasks require integrity of the right and left striatum, respectively, and imply that the pattern of cognitive changes manifest by a patient with PD may reflect differential dopamine loss in the two striatal complexes.