Magnetic resonance properties of ex vivo breast tissue at 1.5 T
Magnetic resonance properties of ex vivo breast tissue at 1.5 T
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DOI：
10.1002/mrm.1910380422
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发表时间：
1997-10-01
影响因子：
3.3
通讯作者：
Bronskill, MJ
中科院分区：
文献类型：
--
作者：
Graham, SJ;Ness, S;Bronskill, MJ
体外乳腺组织在1.5 T和37℃下的磁共振吸收谱、T-1和T-2弛豫时间分布和磁化传递特性已经被表征。单个组织样品（n = 31）中纤维腺组织的比例是通过可分辨的宽线脂肪和水共振积分得到的组织体积含水量推断出来的。光谱估计的水分含量与酶提取的水分含量有很强的相关性（Pearson相关系数0.98,P < < 0.01），这使得纤维腺组织（T-2 = 0.04 +/- 0.01, T-1 = 1.33 +/- 0.24 s）和脂肪组织（T-2 = 0.13 +/- 0.01, T-1 = 0.23 +/- 0.01 s, T-2 = 0.38 +/- 0.03, T-1 = 0.62 +/- 0.16 s）的主松弛成分的分配成为可能。纤维腺组织松弛成分表现出较强的磁化转移作用，脂肪组织松弛成分表现出较弱的磁化转移作用。这些结果最终对乳腺临床磁共振成像的优化和研究调查具有一定的适用性。
The magnetic resonance absorption spectrum, T-1 and T-2 relaxation time distributions, and magnetization transfer properties of ex vivo breast tissue have been characterized at 1.5 T and 37 degrees C. The fraction of fibroglandular tissue within individual tissue samples (n = 31) was inferred from the tissue volumetric water content obtained by integration of resolvable broad-line fat and water resonances. The spectroscopically estimated water content was strongly correlated with that extracted enzymatically (Pearson correlation coefficient 0.98, P < < 0.01), which enabled the assignment of principal relaxation components for fibroglandular tissue (T-2 = 0.04 +/- 0.01, T-1 = 1.33 +/- 0.24 s), and for adipose tissue (T-2 = 0.13 +/- 0.01, T-1 = 0.23 +/- 0.01 s, and T-2 = 0.38 +/- 0.03, T-1 = 0.62 +/- 0.16 s). The relaxation components for fibroglandular tissue exhibited strong magnetization transfer, whereas those for adipose tissue showed little magnetization transfer effect. These results ultimately have applicability to the optimization of clinical magnetic resonance imaging and research investigations of the breast.