Polymerisation, antibacterial and bioactivity properties of experimental orthodontic adhesives containing triclosan-loaded halloysite nanotubes
Polymerisation, antibacterial and bioactivity properties of experimental orthodontic adhesives containing triclosan-loaded halloysite nanotubes
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DOI：
10.1016/j.jdent.2017.11.002
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发表时间：
2018-02-01
影响因子：
4.4
通讯作者：
Sauro, Salvatore
中科院分区：
文献类型：
--
作者：
Degrazia, Felipe Weidenbach;Genari, Bruna;Sauro, Salvatore
目的：评价三种三氯生纳米管粘结剂的即刻釉质粘接强度、原位转化率和聚合率。材料和方法：将不同浓度(5wt%、10wt%和20wt%)的三氯环己烷负载埃洛石纳米管(TCN-HNT)添加到树脂混合物中(对照组)，制备了3种实验正畸粘结剂。用FTIR分析了粘接剂的最大聚合速率，用拉曼光谱分析了托槽/牙釉质界面的原位转化率(DC)。结果：TCN-HNT的加入增加了粘接剂的聚合性能，但不影响粘接剂的即时粘接性能。所有含有TCN-HNT的实验粘结剂在24小时内抑制细菌生长，并在AS储存14天后诱导矿物质沉积。在72 h时，只有含有20%TCN-HNT的实验体系才能保持这种能力。结论：TCN-HNT掺杂后的胶粘剂具有更好的聚合性能和合适的粘接性能。然而，只有含有TCN-HNT>；10%的粘结剂才能促进长期的抗菌活性和可靠的矿物沉积。临床意义：使用含有三氯生的粘结剂代表了一种很有前途的粘结正畸托槽和牙带的“智能”方法；这些粘结剂可能会在治疗过程中防止釉质脱矿和诱导釉质再矿化。
Objective: To evaluate the immediate enamel bond strength, in situ degree of conversion and the polymerisation rate of three experimental orthodontic adhesives containing triclosan-loaded halloysite nanotubes. The antibacterial and bioactivity properties of such experimental materials were also assessed.Materials and methods: Three experimental orthodontic adhesives were formulated by incorporating triclosanloaded halloysite nanotubes (TCN-HNT) at different concentrations (5 wt%, 10 wt% and 20 wt%) into a resin blend (Control). The maximum polymerisation rate of the tested adhesives was evaluated trough FTIR, while Raman was used to analyse the in situ degree of conversion (DC) at the bracket/enamel interface. The shear bond strength (SBS) of the enamel-bonded specimens was assessed at 24 h. The antibacterial properties of the experimental materials against S. Mutans were evaluate up to 72 h, while, their bioactivity was evaluated after 14 days of artificial saliva (AS) storage through SEM-EDS and Raman spectromicroscopy.Results: Incorporation of TCN-HNT increased the polymerisation properties without interfering with the immediate bonding properties of the experimental adhesives. All experimental adhesives containing TCN-HNT inhibited bacterial growth at 24 h, and induced mineral deposition after 14 days of AS storage. At 72 h, only the experimental system containing 20% TCN-HNT maintained such a capability.Conclusions: Adhesives doped with TCN-HNT present improved polymerisation properties and suitable bonding performance. However, only the adhesives containing TCN-HNT > 10% might promote long-term antibacterial activity and reliable mineral deposition.Clinical significance: The use of adhesives containing triclosan-loaded halloysite represents a promising "smart" approach to bond orthodontic brackets and bands; these might prevent enamel demineralisation and induce enamel remineralisation during the treatment.