Assessment of critical closing pressure in the cerebral circulation as a measure of cerebrovascular tone
Assessment of critical closing pressure in the cerebral circulation as a measure of cerebrovascular tone
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DOI：
10.1007/s007010050422
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发表时间：
1999-01-01
影响因子：
2.4
通讯作者：
Pickard, JD
中科院分区：
文献类型：
--
作者：
Richards, HK;Czosnyka, M;Pickard, JD
根据血流速度（FV）和动脉血压（ABP）波形计算的临界闭合压（CCP）先前已被报道用于评估脑循环动力学。我们在22只新西兰白色兔的颅内高压模型中，研究了在动脉CO2、ABP和缺氧引起的血管舒张期间CCP与颅内压（ICP）和脑血管张力的关系。在蛛网膜下腔灌注生理盐水期间记录基底动脉FV、ABP和ICP。在输注期间ICP和CCP显著相关（R = 0.68; p < 0.001），但在输注期间ICP和CCP的增加幅度彼此不相关。差异之间的线性回归：CCP-ICP（代表血管紧张性的一个因素）和脑灌注压（CPP = ABP-ICP）非常显著（R = -0.87; p < 0.01）。结果显示，在高碳酸血症、低血压、缺氧前后，CCP均显著降低（P < 0.05），差异有显著性（P < 0.05），CCP-ICP在每次扩血管后均持续降低，CCP与ICP、CCP-ICP差值与脑血管张力呈线性关系。然而，由于ICP增加的幅度与变化的幅度无关。
Critical closing pressure (CCP) calculated from the blood how velocity (FV) and arterial blood pressure (ABP) waveforms has been previously reported to be useful in the assessment of the dynamics of cerebral circulation. We investigated the relationship between CCP and intracranial pressure (ICP) and cerebrovascular tone in a model of intracranial hypertension in 22 anaesthetised New Zealand White rabbits during manipulations of arterial CO2, ABP and vasodilatation caused by hypoxia. Recordings were made of FV in the basilar artery, ABP and ICP during subarachnoid infusion of saline. During infusion ICP and CCP were significantly correlated (R = 0.68; p < 0.001), but the magnitude of increase in ICP and CCP during infusion were not correlated to each other. Linear regression between the difference: CCP-ICP (representing a factor due to vasogenic tone) and cerebral perfusion pressure (CPP = ABP-ICP) was highly significant (R = -0.87; p < 0.01). Generally, CCP decreased significantly (p < 0.05) with hypercarbia, arterial hypotension and after and post-hypoxia and the difference: CCP-ICP decreased consistently after each vasodilatatory manoeuvre studied.Our data confirmed the linear relationship between CCP and ICP, and between the difference: CCP-ICP and cerebrovascular tone. However, because the magnitude of increase in ICP was not con-elated to magnitude of change.