Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer.
Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer.
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DOI：
10.3892/or.13.2.247
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发表时间：
2005-02
期刊：
影响因子：
4.2
通讯作者：
Masanori Yoshino;T. Ishiwata;M. Watanabe;Osamu Komine;T. Shibuya;A. Tokunaga;Z. Naito
中科院分区：
文献类型：
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作者：
Masanori Yoshino;T. Ishiwata;M. Watanabe;Osamu Komine;T. Shibuya;A. Tokunaga;Z. Naito
角质形成细胞生长因子受体，也称为KGFR/FGFR 2 IIIb，主要位于上皮细胞中并参与这些细胞的增殖。在本研究中，我们试图阐明KGFR在人结直肠癌中的表达和作用。在几种结直肠癌细胞系中检测到KGFR蛋白。免疫组化显示，KGFR在正常大肠组织中表达于上皮细胞的腔面。KGFR在56例结直肠癌患者中有35例（62.5%）表达，并位于癌巢的中心。细胞角蛋白20（CK 20）与KGFR共定位。相比之下，Ki-67定位于癌巢的外围。在临床病理学上，KGFR高表达与高分化组织学类型（p<0.0001）和浅壁浸润（p<0.0174）相关。这些结果表明，KGFR可能在正常大肠上皮细胞的分化和大肠癌细胞的高分化组织学类型的建立中起重要作用。
The keratinocyte growth factor receptor, also known as KGFR/FGFR2 IIIb, is mainly localized in epithelial cells and participates in the proliferation of these cells. In the present study, we attempted to clarify the expression and role of KGFR in human colorectal cancer. The KGFR protein was detected in several colorectal cancer cell lines. Immuno-histochemically, KGFR was expressed on the luminal surface of epithelial cells in normal colorectal tissues. KGFR was expressed in 35 of 56 (62.5%) colorectal cancer patients and localized at the center of the cancer nests. Cytokeratin 20 (CK 20) colocalized with KGFR. In contrast, Ki-67 localized at the periphery of the cancer nests. Clinicopathologically, a high level of KGFR expression was associated with well-differentiated histological type (p<0.0001) and shallow wall invasion (p<0.0174). These findings indicate that KGFR may play important roles in the differentiation of normal colorectal epithelial cells and establishment of the well-differentiated histological type of colorectal cancer cells.