The sexual identity of adult intestinal stem cells controls organ size and plasticity.
The sexual identity of adult intestinal stem cells controls organ size and plasticity.
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DOI：
10.1038/nature16953
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发表时间：
2016-02-18
期刊：
影响因子：
64.8
通讯作者：
Miguel-Aliaga I
中科院分区：
文献类型：
--
作者：
Hudry B;Khadayate S;Miguel-Aliaga I
生理和疾病易感性的性别差异通常归因于发育和/或激素因素，但越来越多的人认识到细胞内在机制发挥着重要和持久的作用。在这里，我们使用果蝇肠道调查的性质和意义的细胞性别在体内的成年体器官。我们发现成人肠上皮是不同性别分化途径的细胞镶嵌体，并且在生长和代谢基因的表达上表现出广泛的性别差异。成体肠道干细胞性别特征的细胞特异性逆转揭示了其在控制器官大小、生殖可塑性和对遗传诱导肿瘤的反应中的关键作用。与以前的例子性二态体干细胞的活动，肠干细胞行为的性别差异产生的内在机制，控制细胞周期的持续时间，并涉及一个新的doublemex和无果的独立分支的性别分化途径下游的Transformer。总之，我们的研究结果表明，成人躯体器官的可塑性是由其性别身份可逆地控制，由一种新的机制赋予，这种机制可能在比以前认识到的更多的组织中起作用。
Sex differences in physiology and disease susceptibility are commonly attributed to developmental and/or hormonal factors, but there is increasing realisation that cell-intrinsic mechanisms play important and persistent roles. Here we use the Drosophila melanogaster intestine to investigate the nature and significance of cellular sex in an adult somatic organ in vivo. We find that the adult intestinal epithelium is a cellular mosaic of different sex differentiation pathways, and displays extensive sex differences in expression of genes with roles in growth and metabolism. Cell-specific reversals of the sexual identity of adult intestinal stem cells uncover its key roles in controlling organ size, its reproductive plasticity and its response to genetically induced tumours. Unlike previous examples of sexually dimorphic somatic stem cell activity, the sex differences in intestinal stem cell behaviour arise from intrinsic mechanisms, which control cell cycle duration and involve a new doublesex- and fruitless-independent branch of the sex differentiation pathway downstream of transformer. Together, our findings indicate that the plasticity of an adult somatic organ is reversibly controlled by its sexual identity, imparted by a new mechanism that may be active in more tissues than previously recognised.
影响因子：
3.7
作者：
Ruiz MF;Sarno F;Zorrilla S;Rivas G;Sánchez L
通讯作者：
Sánchez L