ACUTE INTESTINAL ISCHEMIA STUDIES BY PHOSPHORUS NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY
ACUTE INTESTINAL ISCHEMIA STUDIES BY PHOSPHORUS NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY
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DOI：
10.1097/00000658-198607000-00012
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发表时间：
1986-07-01
影响因子：
9
通讯作者：
BUZBY, GP
中科院分区：
文献类型：
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作者：
BLUM, H;SUMMERS, JJ;BUZBY, GP
应用31P核磁共振（NMR）技术观察急性缺血大鼠小肠代谢及缺血逆转后小肠恢复情况。小肠袢受到封闭的外部压力长达60分钟，随后是恢复期。PCr和ATP的消耗是快速的，在20分钟内完成。缺血恢复也很快，但在长时间缺血后，恢复ATP水平低于初始值。避免了肠道休克。临床恢复与缺血时间缩短相关。因此，核磁共振波谱似乎是一种合适的技术，用于研究药物和其他治疗方法对改善肠道缺血效应的影响。
31P nuclear magnetic (NMR) spectroscopy has been used to follow the metabolism of acutely ischemic rat small intestine and its recovery after reversal of ischemia. Loops of small intestine were subjected to occlusive external pressure for up to 60 minutes, followed by a recovery period. The depletion of PCr and ATP is rapid and complete within 20 minutes. Recovery from ischemia is also rapid but with recovery ATP levels lower than initial values after prolonged ischemic periods. Intestinal shock was avoided. Clinical recovery correlated with shorter ischemic periods. 31P NMR spectroscopy thus appears to be a suitable technique for studying the effects of pharmacological agents and other treatments for amelioration of ischemic effects on the bowel.