The thiyl radical-mediated isomerization of cis-monounsaturated fatty acid residues in phospholipids:: a novel path of membrane damage?
The thiyl radical-mediated isomerization of cis-monounsaturated fatty acid residues in phospholipids:: a novel path of membrane damage?
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DOI：
10.1039/a809674k
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发表时间：
1999-03-07
影响因子：
4.9
通讯作者：
Chatgilialoglu, C
中科院分区：
文献类型：
--
作者：
Ferreri, C;Costantino, C;Chatgilialoglu, C
硫基自由基是在仿生条件下由生物相关硫醇产生的，可逆地攻击脂质溶液或脂质囊泡中含有顺式脂肪酸残基的不饱和磷脂的双键，从而高产率地产生含有反式脂肪酸残基的磷脂。
Thiyl radicals, generated from biologically relevant thiols under biomimetic conditions, reversibly attack the double bonds of unsaturated phospholipids containing cis-fatty acid residues either in lipid solutions or lipid vesicles, thus producing phospholipids containing trans-fatty acid residues in high yield.