Regionally diverse cortical pathology in schizophrenia: clues to the etiology of the disease.
Regionally diverse cortical pathology in schizophrenia: clues to the etiology of the disease.
复制标题
精神分裂症的区域多样化皮质病理学：该疾病病因学的线索。
DOI：
10.1093/oxfordjournals.schbul.a006881
复制
发表时间：
2001
影响因子：
6.6
通讯作者：
Selemon,LD
中科院分区：
文献类型：
--
作者：
Selemon,LD
也许最近对精神分裂症的病理学研究中出现的最令人惊讶的发现是这种疾病明显的皮质区域异质性。许多参数的区域特异性变化已有报道(如神经元密度、γ-氨基丁酸免疫反应细胞密度、突触相关蛋白和信使核糖核酸浓度S)。在过去的5年里，随着大量看似相互矛盾的发现的发表，不同的发现往往被认为是尸检研究不可复制和徒劳的进一步证据。尽管发现中的一些差异可能是由于方法的差异或对不同患者队列的研究，但越来越多的实验室正在单个大脑队列的多个皮质区域检查相同的参数(S)，并发现特定区域的异常。这些发现提供了令人信服的证据，表明精神分裂症的皮质病理学是不统一和复杂的。当代精神分裂症研究的一个主要挑战是理解精神分裂症全脑病理的模式，因为神经病理变化的马赛克可能为疾病病因提供线索。
Perhaps the most surprising revelation that has emerged from recent pathologic studies of schizophrenia is the marked cortical regional heterogeneity of the disease. Areal specific alterations of many parameters have been reported (e.g., neuronal density, density of γ-aminobutyric acid [GABA]-immunoreactive cells, and concentration of synapse-associated proteins and messenger ribonucleic acid [mRNA]s). In the past 5 years, as a flood of seemingly contradictory findings have been published, divergent findings often have been regarded as further evidence of the irreplicability and futility of postmortem studies. Although some discrepancies in findings may be due to methodological differences or to the study of different cohorts of patients, a growing number of laboratories are examining the same parameter(s) in multiple cortical areas in a single brain cohort and finding regionally specific abnormalities. These findings provide compelling evidence that cortical pathology in schizophrenia is nonuniform and complex. A major challenge in contemporary schizophrenia research is to make sense of the patterning of whole brain pathology in schizophrenia, as the mosaic of neuropathologic alterations may provide clues to the disease etiology.