The human major histocompatibility complex and endocrine disease.
The human major histocompatibility complex and endocrine disease.
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人类主要是组织相容性复合体和内分泌疾病。
作者：
N. Farid;J. Bear
主要组织相容性复合体（MHC）中的基因座与几种内分泌疾病的易感性之间存在相关性。对于更常见的内分泌疾病，这种关系在疾病与特定等位基因的统计学关联中得到证明，对此有几种可能的解释。最有可能的是，这些关联表明与标记等位基因连锁不平衡的免疫应答基因的影响，但这绝不是证明。一个普遍的协会是注意到的DR 3等位基因的组织相容性（HLA）-DR系统与自身免疫性内分泌疾病，这可能是通过免疫促进，而不是疾病特异性易感性。DR 4和胰岛素依赖型糖尿病（IDDM）之间的一个更具体的关联被认为是存在的糖尿病基因或附近的MHC。同样，DR 5与甲状腺炎（DR 3与萎缩性甲状腺炎）的相关性表明可能与甲状腺肿形成机制有关。这些...
ARELATIONSHIP is found between loci in the major histocompatibility complex (MHC) and susceptibility to several endocrine disorders. For the more common endocrine diseases the relationship is evidenced in statistical associations of disease with specific alleles, for which several explanations are possible. The most likely is that these associations indicate the influence of immune response genes in linkage disequilibrium with the marker allele, but this is by no means proven. A pervasive association is noted of the DR3 allele of the histocompatibility (HLA)-DR system with autoimmune endocrine disease; this may be by way of immunological facilitation rather than disease-specific predisposition. A more specific association between DR4 and insulindependent diabetes mellitus (IDDM) is seen, suggesting the existence of a diabetogenic gene in or near the MHC. Likewise, the association of DR5 with goitrous (and DR3 with atrophic) thyroiditis suggests a possible link to the mechanism of goiter formation. These a...