BLOOD ION REGULATION DURING REPEATED MAXIMAL EXERCISE AND RECOVERY IN HUMANS
BLOOD ION REGULATION DURING REPEATED MAXIMAL EXERCISE AND RECOVERY IN HUMANS
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DOI：
10.1152/ajpregu.1992.262.1.r126
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发表时间：
1992-01-01
影响因子：
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通讯作者：
JONES, NL
中科院分区：
文献类型：
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作者：
LINDINGER, MI;HEIGENHAUSER, GJF;JONES, NL
我们研究了在重复的最大强度运动中伴随肌肉疲劳的动脉血（a）和股静脉血（fv）中的离子变化。对分离的血浆和溶血全血进行测量，以定量血浆和红细胞对该酸碱挑战的相对贡献。五名健康男性进行了四个30秒的最大等速循环运动，与4分钟的休息之间的回合，并恢复90分钟。在全血中，最大增加[K+]a达10 +/- 2.0 meq/l和[K+]Fv至7 +/- 4.3 meq/l，并发生在回合结束2。在第4回合结束时，全血乳酸盐浓度（[Lac-]）达到峰值15.3 +/- 1.39（[Lac-]a）和16.7 +/- 1.59 meq/l（[Lac-]fv）。在血浆中，峰值[Lac-]a和[Lac-]fv在第4回合结束时均为21 meq/l。血浆[H+]a从静息时的36 +/- 1.0 neq/l增加到第一次运动结束时的44 +/- 2.9 neq/l;这种增加的80%是由于动脉强离子差（[SID]）减少2.9 meq/l，20%是由于血浆蛋白（[A（tot）]a）增加;动脉PCO 2降低至29 mmHg具有碱化作用。相比之下，血浆[H+]fv从静息时的39 +/- 0.5 neq/l增加至93 +/- 4.1 neq/l，Pfv（CO2）增加至97 +/- 7 mmHg贡献了75%，[SID]fv降低15%，[A（tot）]fv增加10%。在以后的运动中，[SID]a、[A（tot）]a和动脉PCO 2对血浆[H+]a的相对贡献相似，但[SID]fv对[H+]fv的贡献增加，股静脉PCO 2的贡献减少，[A（tot）]fv的贡献保持不变（8-12%）。在运动和恢复过程中，动脉和股静脉PCO 2和[K+]的变化均比[Lac-]的变化快，全血[K+]的时程比血浆[K+]的时程慢。红细胞在剧烈运动时对血浆[Lac-]和[K+]的调节中可能起重要作用。
We investigated the ionic changes in arterial (a) and femoral venous (fv) blood that accompany muscle fatigue with repeated maximal exercise. Measurements were made on separated plasma and hemolysed whole blood to quantify the relative contributions of plasma and erythrocytes to this acid-base challenge. Five healthy males performed four 30-s bouts of maximal isokinetic cycling exercise, with 4 min of rest between bouts, and recovery was followed for 90 min. In whole blood, maximal increases in [K+]a amounted to 10 +/- 2.0 meq/l and in [K+]fv to 7 +/- 4.3 meq/l and occurred at the end of bout 2. Whole blood lactate concentration ([Lac-]) peaked at 15.3 +/- 1.39 ([Lac-]a) and 16.7 +/- 1.59 meq/l ([Lac-]fv) at the end of bout 4. In plasma, peak [Lac-]a and [Lac-]fv were both 21 meq/l at the end of bout 4. Plasma [H+]a increased from 36 +/- 1.0 neq/l at rest to 44 +/- 2.9 neq/l at the end of the first bout of exercise; 80% of this increase was due to a 2.9 meq/l decrease in arterial strong ion difference ([SID]), and 20% was due to an increase in plasma protein ([A(tot)]a); a reduction in arterial PCO2 to 29 mmHg had an alkalinizing effect. In contrast, plasma [H+]fv increased from 39 +/- 0.5 neq/l at rest to 93 +/- 4.1 neq/l, with an increase in Pfv(CO2) to 97 +/- 7 mmHg contributing 75%, a decrease in [SID]fv 15%, and an increase in [A(tot)]fv 10% to the increase in [H+]fv. In later exercise bouts, the relative contributions of [SID]a, [A(tot)]a, and arterial PCO2 to plasma [H+]a were similar, but the contribution of [SID]fv to [H+]fv increased and that of femoral venous PCO2 decreased, with the contribution of [A(tot)]fv remaining unchanged (8-12%). During exercise and recovery, the changes in both arterial and femoral venous PCO2 and [K+] were more rapid than changes in [Lac-], and the time course of whole blood [K+] was slower than that of plasma [K+]. Erythrocytes may play an important role in regulating plasma [Lac-] and [K+] with intense exercise.