The Effects of Continuous Clonidine Infusion on the Circadian Rhythms of Arterial Blood Pressure, Heart Rate and Spontaneous Locomotor Activity in Normotensive Wistar-Kyoto Rats
The Effects of Continuous Clonidine Infusion on the Circadian Rhythms of Arterial Blood Pressure, Heart Rate and Spontaneous Locomotor Activity in Normotensive Wistar-Kyoto Rats
复制标题
连续输注可乐定对正常血压 Wistar-Kyoto 大鼠动脉血压、心率和自发活动昼夜节律的影响
DOI：
10.1007/978-1-349-07837-0_19
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
B. Jarrott
中科院分区：
文献类型：
--
作者：
S. Lewis;B. Jarrott
在大鼠中，已经充分确立了许多生理、生化和行为系统中的昼夜节律的存在（Sheving等人，1968; Rusak和Zucker，1975; Rosenfeld和Rice，1979）。然而，对于动脉血压是否存在这样的节律存在争议。尽管Friberg等人（1982）报告血压正常大鼠的血压在暗相期间高于亮相，但Norman等人（1980）未发现该参数存在昼夜节律的证据。然而，似乎药物的心血管作用可能由于迷走神经和交感神经活动、激素释放以及心脏和血管的反应性中的昼夜节律的存在而复杂化（Rusak和Zuker，1979; Hossman等人，1980年）。例如，Brown和Lever（1982）证明，在正常血压大鼠中连续输注血管紧张素II的升压作用在4天输注期的黑暗阶段更为显著。
In rats, the existence of circadian rhythms in many physiological, biochemical and behavioural systems has been well established (Sheving et al, 1968; Rusak and Zucker, 1975; Rosenfeld and Rice, 1979). However, controversy exists as to whether or not such rhythms exist for arterial blood pressure. Although Friberg et al (1982) reported that the blood pressure of normotensive rats was higher during the dark phase than the light phase, Norman et al (1980) did not find evidence for a circadian rhythm in this parameter. Nevertheless, it appears that the cardiovascular effects of drugs could be complicated by the presence of circadian rhythms in vagal and sympathetic activity, hormone release and the responsiveness of the heart and blood vessels (Rusak and Zuker, 1979; Hossman et al., 1980). For example, Brown and Lever (1982) demonstrated that the pressor effects of a continuous infusion of angiotensin II in normotensive rats were more dramatic during the dark phases of a four day infusion period.