Mix‐breeding with HEV‐infected swine induced inapparent HEV infection in SPF rabbits
Mix‐breeding with HEV‐infected swine induced inapparent HEV infection in SPF rabbits
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DOI：
10.1002/jmv.24374
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发表时间：
2016-04
影响因子：
12.7
通讯作者：
Lin Liu;Lin Wang;Junke Xia;Yulin Zhang;H. Zeng;P. Liu;Qing-hua Zou;Ling Wang;H. Zhuang
中科院分区：
文献类型：
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作者：
Lin Liu;Lin Wang;Junke Xia;Yulin Zhang;H. Zeng;P. Liu;Qing-hua Zou;Ling Wang;H. Zhuang
研究表明，猪戊型肝炎病毒（sHEV）和兔戊型肝炎病毒（rHEV）可分别感染家兔和猪。然而，迄今为止，还没有公开的数据记录在自然环境中从兔中分离sHEV毒株。为了阐明sHEV自然跨种属传播至家兔的可能性，将HEV感染猪与SPF家兔一起沿着饲养在同一封闭空间内。从混合饲养后第3周起，10只家兔中有5只出现抗HEV抗体血清转化。10只家兔的粪便、血清、肝脏和胆汁中均未检出HEV RNA，ALT也未明显升高。结果提示sHEV可能通过粪口途径引起SPF兔隐性感染。医学病毒学杂志88：681 - 685，2016.© 2015威利期刊公司.
Studies have shown that swine HEV (sHEV) and rabbit HEV (rHEV) can experimentally infect rabbits and swine, respectively. However, no published data have documented isolating sHEV strains from rabbits in natural environment so far. To clarify the possibility of natural cross‐species transmission of sHEV to rabbits, the pigs with HEV infection were farmed along with SPF rabbits in the same enclosed space. Five of 10 rabbits had seroconversion for anti‐HEV antibody from the third week after mix‐breeding. However, HEV RNA remained undetectable in feces, serum, liver and bile of the ten rabbits; and no obvious elevation of ALT was observed. The results possibly suggested that sHEV might lead to an inapparent infection of SPF rabbits by fecal‐oral route. J. Med. Virol. 88:681–685, 2016. © 2015 Wiley Periodicals, Inc.