Bioactive nanoparticle through postmodification of colloidal silica.
Bioactive nanoparticle through postmodification of colloidal silica.
复制标题
DOI：
10.1021/am5014858
复制
发表时间：
2014-03
影响因子：
9.5
通讯作者：
Chen Wang;Y. Xie;Ailing Li;Hong Shen;Decheng Wu;D. Qiu
中科院分区：
文献类型：
--
作者：
Chen Wang;Y. Xie;Ailing Li;Hong Shen;Decheng Wu;D. Qiu
以Ca(OH)2为改性剂，对二氧化硅胶体纳米粒子进行表面改性，合成了粒径可控、胶体稳定性好的生物活性纳米粒子。这些修饰的纳米颗粒表现出良好的生物活性，在模拟体液中培养3天后显示出羟基磷灰石形成的证据。从纳米级到微米级比较了不同粒径颗粒的生物活性。在研究的粒径范围内，钙修饰二氧化硅胶体颗粒的生物活性普遍随粒径的增大而降低（40 nm颗粒在1天内显示出生物活性）。这些颗粒也被发现是无细胞毒性的，但可以促进成骨前细胞的生长，因此使它们成为骨修复材料中有前景的生物活性添加剂。
Bioactive nanoparticles with controllable size and good colloidal stability were synthesized through surface modification of colloidal silica nanoparticles with Ca(OH)2 as the modifier. These modified nanoparticles showed good bioactivity, showing evidence of hydroxyapatite formation when incubated in simulated body fluid within 3 days. Comparison of bioactivity was made among different sized particles from nanoscale to microscale. It was found the bioactivity of these calcium modified colloidal silica particles generally decreased with particle size in the explored size range (40 nm particles showed bioactivity within 1 day). These particles were also found to be noncytotoxic but promote preosteoblast growth, thus making them promising bioactive additives for bone repair materials.