Erectile dysfunction and subsequent cardiovascular disease
Erectile dysfunction and subsequent cardiovascular disease
复制标题
DOI：
10.1001/jama.294.23.2996
复制
发表时间：
2005-12-21
影响因子：
120.7
通讯作者：
Coltman, CA
中科院分区：
文献类型：
--
作者：
Thompson, IM;Tangen, CM;Coltman, CA
研究背景心血管疾病和勃起功能障碍的危险因素是相似的。随机分配至安慰剂组的55岁或以上男性（n=9457）在美国221个中心的前列腺癌预防试验中，每3个月对心血管疾病和勃起功能障碍进行一次评估，1994年和2003年。比例风险回归模型被用来评估勃起功能障碍和心血管疾病的关联。在调整模型中，协变量包括年龄、体重指数、血压、血脂、糖尿病、心肌梗死家族史、种族、吸烟史、体力活动和生活质量。主要结果测量勃起功能障碍和心血管疾病。在这些男性中，3816人（47%）在研究开始时患有勃起功能障碍。在4247名在研究开始时没有勃起功能障碍的男性中，2420名男性（57%）在5年后报告了勃起功能障碍事件。校正后，勃起功能障碍事件与研究随访期间后续心血管事件的风险比为1.25（95%置信区间[CI]，1.02-1.53; P=.04）。对于偶发性或普遍性勃起功能障碍的男性，风险比为1.45（95%CI，1.25-1.69; P
Context The risk factors for cardiovascular disease and erectile dysfunction are similarObjective To examine the association of erectile dysfunction and subsequent cardiovascular disease.Design, Setting, and Participants Men aged 55 years or older who were randomized to the placebo group (n=9457) in the Prostate Cancer Prevention Trial at 221 US centers were evaluated every 3 months for cardiovascular disease and erectile dysfunction between 1994 and 2003. Proportional hazards regression models were used to evaluate the association of erectile dysfunction and cardiovascular disease. In an adjusted model, covariates included age, body mass index, blood pressure, serum lipids, diabetes, family history of myocardial infarction, race, smoking history, physical activity, and quality of life.Main Outcome Measures Erectile dysfunction and cardiovascular disease.Results Of the 9457 men randomized to placebo, 8063 (85%) had no cardiovascular disease at study entry; of these men, 3816 (47%) had erectile dysfunction at study entry. Among the 4247 men without erectile dysfunction at study entry, 2420 men (57%) reported incident erectile dysfunction after 5 years. After adjustment, incident erectile dysfunction was associated with a hazard ratio of 1.25 (95% confidence interval [CI], 1.02-1.53; P=.04) for subsequent cardiovascular events during study follow-up. For men with either incident or prevalent erectile dysfunction, the hazard ratio was 1.45 (95% Cl, 1.25-1.69; P