Prevalence of hepatitis B and C and factors for infection and nonimmune in inflammatory bowel disease patients in China
Prevalence of hepatitis B and C and factors for infection and nonimmune in inflammatory bowel disease patients in China
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DOI：
10.1097/meg.0000000000000838
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发表时间：
2017-05-01
影响因子：
2.1
通讯作者：
Wu, Jianjiong
中科院分区：
文献类型：
--
作者：
Chen, Dafan;Luo, Shengzheng;Wu, Jianjiong
目的探讨炎症性肠病（IBD）患者B肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染的流行情况及与感染和非免疫状态相关的危险因素。分析IBD患者HBV、HCV感染及非免疫状态的相关危险因素。健康体检者为健康对照组，年龄、性别、性别均匹配。IBD组HBV感染率为41.21%，高于普通人群（P=0.003）。在多变量分析中，年龄大于30岁（P=0.000）、溃疡性结肠炎（P=0.002）和既往手术史（P=0.039）是HBV感染的重要危险因素。IBD组中36.43%的患者对乙型肝炎病毒无免疫状态，在多因素分析中，年龄<40岁（P=0.011）和克罗恩病（P=0.002）被确定为独立危险因素。结论我国IBD患者HBV感染率高于欧美国家和我国普通人群，但HCV感染率与普通人群相似。乙肝疫苗接种的非免疫状态发生率较高，尤其是年轻克罗恩病患者，应加强乙肝疫苗接种，并有针对性地进行接种。版权所有（C）2017威科医疗集团All rights reserved.
ObjectiveThe aims of this study were to investigate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in inflammatory bowel disease (IBD) patients and the risk factors related to the infection and nonimmune status.MethodsA retrospective study was carried out at two clinical centers. The prevalence of viral markers and risk factors related to HBV and HCV infection and nonimmune status were analyzed in IBD patients. Age-matched and sex-matched healthy individuals were recruited as the controls.ResultsA total of 980 IBD patients were included in this study. Present and past HBV infection was detected in 41.21% of the IBD group, which was higher than that in the general population (P=0.003). Age older than 30 years (P=0.000), ulcerative colitis (P=0.002), and previous surgery (P=0.039) were found to be significant risk factors for HBV infection in the multivariate analysis. 36.43% of the patients in the IBD group had nonimmune status against HBV, and age less than 40 years (P=0.011) and Crohn's disease (P=0.002) were identified as independent risk factors in the multivariate analysis. The prevalence of HCV infection was low and similar to that of the general population.ConclusionThe prevalence of HBV infection in IBD patients in China was higher than that in Europe, USA, and the general population in China, but the prevalence of HCV infection in IBD patients was similar to that in the general population in this study. The frequency of nonimmune status against HBV was high, especially in young Crohn's disease patients, and HBV vaccination should be intensified and have a targeted coverage. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.