Determinants of bone density in 30-to 65-year-old women: A co-twin study
Determinants of bone density in 30-to 65-year-old women: A co-twin study
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DOI：
10.1359/jbmr.2003.18.9.1650
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发表时间：
2003-09-01
影响因子：
6.2
通讯作者：
Wark, JD
中科院分区：
文献类型：
--
作者：
MacInnis, RJ;Cassar, C;Wark, JD
简介：报道的影响，身体成分和生活方式的骨矿物质密度在老年前的成年women.Methods：在一个共同的双胞胎研究146名女性双胞胎对年龄在30至65岁，DXA被用来测量骨矿物质密度在腰椎，全髋关节，前臂，全身骨矿物质含量，瘦和脂肪质量。测量身高和体重。通过问卷调查确定月经状况、膳食钙摄入量、体力活动、当前吸烟和饮酒情况。通过对假定determinations.Results：瘦体重和脂肪量与更大的骨量在所有网站内的对内差异的起源对骨措施的内对差异进行回归。吸烟10包-年的不一致性与除前臂外所有部位骨密度降低2.3-3.3%（SE，0.8-1.0）有关，其影响在绝经后妇女中更为明显。在所有女性中，髋骨矿物质密度的0.8%（SE，0.3）差异与每周每小时的体育活动差异相关，在绝经前女性中效果更明显。每日膳食钙摄入量与全身骨矿物质含量和前臂骨矿物质密度相关（每1000 mg增加1.4 +/- 0.7%）。终生饮酒量和步行并不一贯相关的bone mass.Conclusion：一些生活方式和饮食因素，特别是烟草的使用，与骨密度。效应大小因研究中心而异。中年及以后骨密度决定因素的特征可能会导致干预措施，可以减少绝经后骨质流失，降低骨质疏松性骨折的风险。
Introduction: Reported effects of body composition and lifestyle of bone mineral density in pre-elderly adult women have been inconsistent.Methods: In a co-twin study of 146 female twin pairs aged 30 to 65 years, DXA was used to measure bone mineral density at the lumbar spine, total hip, and forearm, total body bone mineral content, and lean and fat mass. Height and weight were measured. Menopausal status, dietary calcium intake, physical activity, current tobacco use, and alcohol consumption were determined by questionnaire. Within-pair differences in bone measures were regressed through the origin against within-pair differences in putative determinants.Results: Lean mass and fat mass were associated with greater bone mass at all sites. A discordance of 10 pack-years smoking was related to a 2.3-3.3% (SE, 0.8-1.0) decrease in bone density at all sites except the forearm, with the effects more evident in postmenopausal women. In all women, a 0.8% (SE, 0.3) difference in hip bone mineral density was associated with each hour per week difference in sporting activity, with effects more evident in premenopausal women. Daily dietary calcium intake was related to total body bone mineral content and forearm bone mineral density (1.4 +/- 0.7% increase for every 1000 mg). Lifetime alcohol consumption and walking were not consistently related to bone mass.Conclusion: Several lifestyle and dietary factors, in particular tobacco use, were related to bone mineral density. Effect sizes varied by site. Characterization of determinants of bone mineral density in midlife and thereafter may lead to interventions that could minimize postmenopausal bone loss and reduce osteoporotic fracture risk.