2 MOVEMENT-RELATED FOCI IN THE PRIMATE CINGULATE CORTEX OBSERVED IN SIGNAL-TRIGGERED AND SELF-PACED FORELIMB MOVEMENTS
2 MOVEMENT-RELATED FOCI IN THE PRIMATE CINGULATE CORTEX OBSERVED IN SIGNAL-TRIGGERED AND SELF-PACED FORELIMB MOVEMENTS
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DOI：
10.1152/jn.1991.65.2.188
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发表时间：
1991-02-01
影响因子：
2.5
通讯作者：
TANJI, J
中科院分区：
文献类型：
--
作者：
SHIMA, K;AYA, K;TANJI, J
1. 在感官（视觉、听觉或触觉）触发或自定节奏的前肢按键运动中，记录了猴子扣带皮层的单个单元活动。微电极被插入到广阔的扣带皮层背侧，包括扣带沟的上、下两岸和扣带回的半球内侧壁。总共检查了1042个与任务相关的神经元，其中大多数与按键运动的执行有关。在60%的患者中，运动相关的活动先于远端屈肌的活动。运动相关神经元分布于扣带皮层后部和前部两个病灶，包括扣带沟上、下两岸。通过使用辣根过氧化物酶（HRP）方法，发现后灶在很大程度上重叠到初级运动皮层的前肢区域。约40%的扣带皮层神经元在信号触发和自定节奏运动中表现出等量反应。对自定节奏运动任务表现出选择性或差异性反应的神经元在前扣带皮层比在后扣带皮层更常见。长时间的活动变化，从500毫秒到2秒不等，主要是在自我定节奏之前观察到的，而在触发运动之前观察到的频率要低得多。它们在前扣带皮层中尤其丰富。只有少数神经元的活动与感觉信号的开始时间一致。这些观察结果表明，扣带皮层的前部和后部是不同的实体，参与肢体运动的表现，即使是简单的运动，如本研究中的那些。
1. Single-unit activity in the cingulate cortex of the monkey was recorded during the performance of sensorially (visual, auditory, or tactile) triggered or self-paced forelimb key press movements.2. Microelectrodes were inserted into the broad rostrocaudal expanse of the cingulate cortex, including the upper and lower banks of the cingulate sulcus and the hemispheric medial wall of the cingulate gyrus.3. A total of 1,042 task-related neurons were examined, the majority of which were related to the execution of the key press movements. In > 60% of them, the movement-related activity preceded the activity in the distal flexor muscles.4. The movement-related neurons were distributed, in two foci, in the posterior and anterior parts of the cingulate cortex, both including the upper and lower banks of the cingulate sulcus. The posterior focus was found to largely overlap the area projecting to the forelimb area of the primary motor cortex by the use of the horseradish peroxidase (HRP) method.5. About 40% of the cingulate cortical neurons showed equimagnitude responses during the signal-triggered and self-paced movements. The neurons exhibiting a selective or differential response to the self-paced motor task were more frequently observed in the anterior than in the posterior cingulate cortex.6. The long-lead type of changes in activity, ranging from 500 ms to 2 s, were observed mainly before the self-paced and, much less frequently, before the triggered movements. They were particularly abundant in the anterior cingulate cortex.7. Only a few of the neurons showed activity time-locked to the onset of the sensory signals.8. These observations indicate that the anterior and posterior parts of the cingulate cortex are distinct entities participating in the performance of limb movements, even if the movements are simple, such as those in this study.