EFFECT OF PREDNISOLONE ON RENAL SCARRING IN RATS FOLLOWING INFECTION WITH SERRATIA-MARCESCENS
EFFECT OF PREDNISOLONE ON RENAL SCARRING IN RATS FOLLOWING INFECTION WITH SERRATIA-MARCESCENS
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DOI：
10.3109/08860229309069405
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发表时间：
1993-01-01
期刊：
影响因子：
3
通讯作者：
KUMAZAWA, J
中科院分区：
文献类型：
--
作者：
HARAOKA, M;MATSUMOTO, T;KUMAZAWA, J
肾疤痕被认为是反流性肾病和肾盂肾炎末期的标准。泼尼松龙是一种强效抗炎药，剂量为 1 或 2 mg/kg 可以预防粘质沙雷氏菌感染后大鼠的肾脏瘢痕形成。然而，4 mg/kg 或 8 mg/kg 的泼尼松龙并不能抑制肾疤痕形成。在一项时间进程实验中，感染后 2、5 或 13 天开始用泼尼松龙进行为期 4 天的治疗可以预防肾脏疤痕形成。这些结果表明泼尼松龙可有效预防此类疤痕形成，并建议临床使用该药物来预防肾盂肾炎和反流性肾病后肾疤痕形成。
Renal scarring is considered a criterion of reflux nephropathy and the end stage of pyelonephritis. Prednisolone, a strong anti-inflammatory drug, at doses of 1 or 2 mg/kg prevented renal scarring in rats following infection with Serratia marcescens. Four or 8 mg/kg of prednisolone, however, did not inhibit renal scar formation. In a time course experiment, renal scarring was prevented when 4-day treatment with prednisolone was initiated 2, 5, or 13 days after infection. These results show that prednisolone is effective in preventing such scarring and suggest the clinical use of this drug for preventing renal scar formation after pyelonephritis and reflux nephropathy.