A recurrent subcutaneous tumour of the thumb: a case of a capicua transcriptional repressor ( CIC )‐rearranged sarcoma
A recurrent subcutaneous tumour of the thumb: a case of a capicua transcriptional repressor ( CIC )‐rearranged sarcoma
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拇指复发性皮下肿瘤：Capicua 转录抑制蛋白 (CIC) 重排肉瘤一例
DOI：
10.1111/jdv.15910
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发表时间：
2019
影响因子：
9.2
通讯作者：
Shimizu H.
中科院分区：
文献类型：
--
作者：
Mizukami T.;Yanagi T.;Kitamura S.;Narahira A.;Maeda T.;Hata H.;Takakuwa E.;Doi K.;Sugita S.;Hasegawa T.;Ikenaga H.;Shimizu H.
复发性拇指皮下肿瘤：一例Capicua转录抑制因子（CIC）重排的肉瘤Capicua转录抑制因子（I CIC i）重排的肉瘤是未分化的圆细胞肉瘤的一个亚群，其特征是位于染色体19q13上的I CIC i基因重排。2. [1]最常见的融合伴侣是染色体4q35上的IDUX4i基因。2或10q26。3. [2]最近的报告支持ICIC i重排肿瘤作为独立疾病分类实体的分类，与躯体软组织而不是骨的偏好和比尤文肉瘤更快的疾病进展有关。[[3]]在这里，我们报告了第一例I CIC i重排肉瘤的手指与一个较低的侵略性的临床过程。组织学鉴别诊断包括滑膜肉瘤、尤文肉瘤和尤文样肉瘤。[摘自文章]
A recurrent subcutaneous tumour of the thumb: a case of a capicua transcriptional repressor (CIC)-rearranged sarcoma Capicua transcriptional repressor (I CIC i)-rearranged sarcomas are a subgroup of undifferentiated round cell sarcomas characterized by rearrangement of the I CIC i gene, which is located on chromosome 19q13. 2.[1] The most common fusion partner is the I DUX4 i gene on chromosome 4q35. 2 or 10q26. 3.[2] Recent reports support the classification of I CIC i-rearranged tumours as independent nosologic entities associated with a predilection for somatic soft tissue rather than for bone and a more rapid disease progression than Ewing sarcoma.[[3]] Here, we report the first case of a I CIC i-rearranged sarcoma of the digit with a less aggressive clinical course. The histological differential diagnoses included synovial sarcoma, Ewing sarcoma and Ewing-like sarcoma.[Extracted from the article]