Immobilization of two organometallic complexes into a single cage to construct protein-based microcompartment
Immobilization of two organometallic complexes into a single cage to construct protein-based microcompartment
复制标题
将两种有机金属配合物固定在一个笼子中构建基于蛋白质的微区室
DOI：
10.1039/c6cc00679e
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
S. Abe and T. Ueno
中科院分区：
文献类型：
--
作者：
B. Maity;K. Fukumori;S. Abe and T. Ueno
含有多种酶的天然蛋白质微区室促进细胞内的级联反应。我们使用的脱辅基铁蛋白蛋白的蛋白笼模拟这样的生物区室固定两个有机金属铱和钯配合物到单一的蛋白笼。通过X射线晶体学研究了金属的精确位置及其积累机制。
Natural protein-based microcompartments containing multiple enzymes promote cascade reactions within cells. We use the apo-ferritin protein cage to mimic such biocompartments by immobilizing two organometallic Ir and Pd complexes into the single protein cage. Precise locations of the metals and their accumulation mechanism were studied by X-ray crystallography.