Inverse association between brown adipose tissue activation and white adipose tissue accumulation in successfully treated pediatric malignancy
Inverse association between brown adipose tissue activation and white adipose tissue accumulation in successfully treated pediatric malignancy
复制标题
DOI：
10.3945/ajcn.111.030650
复制
发表时间：
2012-05-01
影响因子：
7.1
通讯作者：
Gilsanz, Vicente
中科院分区：
文献类型：
--
作者：
Chalfant, James S.;Smith, Michelle L.;Gilsanz, Vicente
背景资料：虽然白色脂肪组织（WAT）的积累是疾病的危险因素，但棕色脂肪组织（BAT）被认为对肥胖具有保护作用。目的：我们研究了在恶性肿瘤治疗的儿童中BAT的变化是否与皮下脂肪组织（SAT）和内脏脂肪组织（VAT）的变化有关。设计：我们研究了BAT活性对32例儿童癌症患者的体重、SAT和VAT的影响，这些患者在诊断时的正电子发射断层扫描（PET-CT）扫描显示没有BAT活性。将无病随访时有代谢活性BAT的儿童（BAT+）从诊断到缓解的体重、SAT和VAT变化与无病时没有可视化BAT的儿童（BAT-）进行比较。癌症成功治疗后的随访PET-CT研究（4.7 +/- 2.4个月后）显示19例患者BAT+，但13例患者无活动性BAT（BAT-）。BAT+患者与BAT-患者相比，体重增加明显较少（3.3 +/- 6.6%与11.0 +/- 11.6%; P = 0.02），SAT显著降低（18.2 +/- 26.5%与67.4 +/- 71.7%; P = 0.01）和VAT（22.6 +/- 33.5%与131.6 +/- 171.8%; P = 0.01）。多元回归分析表明，BAT激活和措施的重量，SAT和增值税之间的负相关关系，即使在年龄，糖皮质激素治疗，和季节时，PET-CT扫描获得accounted.Conclusion：BAT在接受治疗的恶性肿瘤的儿科患者的激活与脂肪堆积显着减少。本试验在clinicaltrials.gov上注册为NCT 01517581。美国临床营养杂志2012;95：1144-9。
Background: Although the accumulation of white adipose tissue (WAT) is a risk factor for disease, brown adipose tissue (BAT) has been suggested to have a protective role against obesity.Objective: We studied whether changes in BAT were related to changes in the amounts of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in children treated for malignancy.Design: We examined the effect of BAT activity on weight, SAT, and VAT in 32 pediatric patients with cancer whose positron emission tomography computed tomography (PET-CT) scans at diagnosis showed no BAT activity. Changes in weight, SAT, and VAT from diagnosis to remission for children with metabolically active BAT at disease-free follow-up (BAT+) were compared with those in children without visualized BAT when free of disease (BAT-).Results: Follow-up PET-CT studies (4.7 +/- 2.4 mo later) after successful treatment of the cancer showed BAT+ in 19 patients but no active BAT (BAT-) in 13 patients. BAT+ patients, in comparison with BAT- patients, gained significantly less weight (3.3 +/- 6.6% compared with 11.0 +/- 11.6%; P = 0.02) and had significantly less SAT (18.2 +/- 26.5% compared with 67.4 +/- 71.7%; P = 0.01) and VAT (22.6 +/- 33.5% compared with 131.6 +/- 171.8%; P = 0.01) during treatment. Multiple regression analysis indicated that the inverse relations between BAT activation and measures of weight, SAT, and VAT persisted even after age, glucocorticoid treatment, and the season when the PET-CT scans were obtained were accounted for.Conclusion: The activation of BAT in pediatric patients undergoing treatment of malignancy is associated with significantly less adipose accumulation. This trial was registered at clinicaltrials.gov as NCT01517581. Am J Clin Nutr 2012;95:1144-9.