Sleep deprivation hastens the antidepressant action of fluoxetine
Sleep deprivation hastens the antidepressant action of fluoxetine
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DOI：
10.1007/bf02900200
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发表时间：
1997-04-01
影响因子：
4.7
通讯作者：
Smeraldi, E
中科院分区：
文献类型：
--
作者：
Benedetti, F;Barbini, B;Smeraldi, E
在10名双相抑郁症患者中，5名患者接受氟西汀单药治疗，5名患者接受氟西汀联合完全睡眠剥夺（TSD）治疗，以评估服用能神经元抗抑郁药复方氟西汀和重复周期TSD之间的相互作用。氟西汀联合重复TSD治疗的患者与其他组相比，抑郁症状改善更快。我们讨论了我们的研究结果，假设由于重复TSD增加了氟西汀药物引起的多巴胺能和可能的多巴胺能传递的增强。
Among ten bipolar depressed patients admitted to our psychiatric ward, five patients were treated with fluoxetine alone and five subjects were treated with fluoxetine in association with total sleep deprivation (TSD) in order to evaluate the effect of the interaction between the administration of the serotonergic antidepressant compound fluoxetine and repeated cycles of TSD. Patients treated with fluoxetine plus repeated TSD showed a faster amelioration of depressive symptomatology compared with the other group. We discuss our findings hypothesizing an enhancement in dopaminergic and possibly in serotonergic transmission due to repeated TSD adding to the increase in serotonergic transmission due to fluoxetine medication.