Competing Core Processes in Attention-Deficit/Hyperactivity Disorder (ADHD): Do Working Memory Deficiencies Underlie Behavioral Inhibition Deficits?
Competing Core Processes in Attention-Deficit/Hyperactivity Disorder (ADHD): Do Working Memory Deficiencies Underlie Behavioral Inhibition Deficits?
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DOI：
10.1007/s10802-010-9387-0
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发表时间：
2010-05-01
影响因子：
3.6
通讯作者：
Kofler, Michael J.
中科院分区：
文献类型：
--
作者：
Alderson, R. Matt;Rapport, Mark D.;Kofler, Michael J.
目前的研究检查了多动症的工作记忆和行为抑制模型的竞争预测。使用传统的停止信号任务测量行为抑制，并评估 14 名 ADHD 儿童和 13 名典型发育 (TD) 儿童的中枢执行、语音和视觉空间工作记忆成分 (Baddeley 2007)。自举中介分析表明，视觉空间工作记忆系统和中央执行系统都调节群体成员资格（ADHD、TD）和停止信号任务表现之间的关系。相反，停止信号任务的表现调节了群体成员资格和中央执行过程之间的关系，但无法解释多动症儿童中一贯存在的语音和视觉空间存储/排练缺陷。两种模型的效应大小估计值的比较表明，工作记忆缺陷可能是 ADHD 儿童停止信号任务表现受损的原因。因此，目前的研究结果对现有的多动症模型提出了挑战，这些模型将行为抑制描述为该疾病的核心缺陷。
The current study examined competing predictions of the working memory and behavioral inhibition models of ADHD. Behavioral inhibition was measured using a conventional stop-signal task, and central executive, phonological, and visuospatial working memory components (Baddeley 2007) were assessed in 14 children with ADHD and 13 typically developing (TD) children. Bootstrapped mediation analyses revealed that the visuospatial working memory system and central executive both mediated the relationship between group membership (ADHD, TD) and stop-signal task performance. Conversely, stop-signal task performance mediated the relationship between group membership and central executive processes, but was unable to account for the phonological and visuospatial storage/rehearsal deficits consistently found in children with ADHD. Comparison of effect size estimates for both models suggested that working memory deficits may underlie impaired stop-signal task performance in children with ADHD. The current findings therefore challenge existing models of ADHD that describe behavioral inhibition as a core deficit of the disorder.